1rlc

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[[Image:1rlc.jpg|left|200px]]
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[[Image:1rlc.png|left|200px]]
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==Overview==
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{{ABSTRACT_8142899}}
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The crystal structure of unactivated ribulose 1,5-bisphosphate carboxylase/oxygenase from Nicotiana tabacum complexed with a transition state analog, 2-carboxy-D-arabinitol 1,5-bisphosphate, was determined to 2.7 A resolution by X-ray crystallography. The transition state analog binds at the active site in an extended conformation. As compared to the binding of the same analog in the activated enzyme, the analog binds in a reverse orientation. The active site Lys 201 is within hydrogen bonding distance of the carboxyl oxygen of the analog. Loop 6 (residues 330-339) remains open and flexible upon binding of the analog in the unactivated enzyme, in contrast to the closed and ordered loop 6 in the activated enzyme complex. The transition state analog is exposed to solvent due to the open conformation of loop 6.
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==About this Structure==
==About this Structure==
1RLC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Nicotiana_tabacum Nicotiana tabacum]. The following page contains interesting information on the relation of 1RLC with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb11_1.html Rubisco]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RLC OCA].
1RLC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Nicotiana_tabacum Nicotiana tabacum]. The following page contains interesting information on the relation of 1RLC with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb11_1.html Rubisco]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RLC OCA].
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==Reference==
 
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Crystal structure of the unactivated ribulose 1,5-bisphosphate carboxylase/oxygenase complexed with a transition state analog, 2-carboxy-D-arabinitol 1,5-bisphosphate., Zhang KY, Cascio D, Eisenberg D, Protein Sci. 1994 Jan;3(1):64-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8142899 8142899]
 
[[Category: Nicotiana tabacum]]
[[Category: Nicotiana tabacum]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Eisenberg, D.]]
[[Category: Eisenberg, D.]]
[[Category: Zhang, K Y.J.]]
[[Category: Zhang, K Y.J.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:38:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:55:15 2008''

Revision as of 14:55, 26 June 2008

Image:1rlc.png

Template:STRUCTURE 1rlc

CRYSTAL STRUCTURE OF THE UNACTIVATED RIBULOSE 1, 5-BISPHOSPHATE CARBOXYLASE(SLASH)OXYGENASE COMPLEXED WITH A TRANSITION STATE ANALOG, 2-CARBOXY-D-ARABINITOL 1,5-BISPHOSPHATE


Template:ABSTRACT 8142899

About this Structure

1RLC is a Protein complex structure of sequences from Nicotiana tabacum. The following page contains interesting information on the relation of 1RLC with [Rubisco]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:55:15 2008

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