1rvf

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==Overview==
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{{ABSTRACT_8848050}}
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The three-dimensional structure of intact human rhinovirus 14 (HRV-14) complexed with Fab fragments (Fab17-IA) from a strongly neutralizing antibody that binds bivalently to the virion has been determined to 4.0 angstrom resolution by a combination of X-ray crystallography and cryo-electron microscopy. In contradiction to the most commonly held model of antibody-mediated neutralization, Fab17-IA does not induce a conformational change in the HRV-14 capsid. Instead, the paratope of the antibody undergoes a large conformational change to accommodate the epitope. Unlike any previously described antibody-antigen structure, the conserved framework region of the antibody makes extensive contact with the viral surface. Fab17-IA penetrates deep within the canyon in which the cellular receptor for HRV-14 binds. Hence, it is unlikely that viral quaternary structure evolves merely to evade immune recognition. Instead, the shape and position of the receptor-binding region on a virus probably dictates receptor binding and subsequent uncoating events and has little or no influence on concealing the virus from the immune system.
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==About this Structure==
==About this Structure==
1RVF is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_rhinovirus_14 Human rhinovirus 14], [http://en.wikipedia.org/wiki/Human_rhinovirus_sp. Human rhinovirus sp.] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The following page contains interesting information on the relation of 1RVF with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb20_1.html Poliovirus and Rhinovirus]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVF OCA].
1RVF is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_rhinovirus_14 Human rhinovirus 14], [http://en.wikipedia.org/wiki/Human_rhinovirus_sp. Human rhinovirus sp.] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The following page contains interesting information on the relation of 1RVF with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb20_1.html Poliovirus and Rhinovirus]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVF OCA].
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==Reference==
 
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Neutralizing antibody to human rhinovirus 14 penetrates the receptor-binding canyon., Smith TJ, Chase ES, Schmidt TJ, Olson NH, Baker TS, Nature. 1996 Sep 26;383(6598):350-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8848050 8848050]
 
[[Category: Human rhinovirus 14]]
[[Category: Human rhinovirus 14]]
[[Category: Human rhinovirus sp.]]
[[Category: Human rhinovirus sp.]]
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[[Category: Rna-directed rna polymerase]]
[[Category: Rna-directed rna polymerase]]
[[Category: Thiol protease]]
[[Category: Thiol protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:57:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:55:55 2008''

Revision as of 14:55, 26 June 2008

Image:1rvf.png

Template:STRUCTURE 1rvf

FAB COMPLEXED WITH INTACT HUMAN RHINOVIRUS


Template:ABSTRACT 8848050

About this Structure

1RVF is a Protein complex structure of sequences from Human rhinovirus 14, Human rhinovirus sp. and Mus musculus. The following page contains interesting information on the relation of 1RVF with [Poliovirus and Rhinovirus]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:55:55 2008

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