1thj

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[[Image:1thj.gif|left|200px]]
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==Overview==
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{{ABSTRACT_8665839}}
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A carbonic anhydrase from the thermophilic archaeon Methanosarcina thermophila that exhibits no significant sequence similarity to known carbonic anhydrases has recently been characterized. Here we present the structure of this enzyme, which adopts a left-handed parallel beta-helix fold. This fold is of particular interest since it contains only left-handed crossover connections between the parallel beta-strands, which so far have been observed very infrequently. The active form of the enzyme is a trimer with three zinc-containing active sites, each located at the interface between two monomers. While the arrangement of active site groups differs between this enzyme and the carbonic anhydrases from higher vertebrates, there are structural similarities in the zinc coordination environment, suggestive of convergent evolution dictated by the chemical requirements for catalysis of the same reaction. Based on sequence similarities, the structure of this enzyme is the prototype of a new class of carbonic anhydrases with representatives in all three phylogenetic domains of life.
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==About this Structure==
==About this Structure==
1THJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanosarcina_thermophila Methanosarcina thermophila]. The following page contains interesting information on the relation of 1THJ with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb49_1.html Carbonic Anhydrase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1THJ OCA].
1THJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanosarcina_thermophila Methanosarcina thermophila]. The following page contains interesting information on the relation of 1THJ with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb49_1.html Carbonic Anhydrase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1THJ OCA].
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==Reference==
 
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A left-hand beta-helix revealed by the crystal structure of a carbonic anhydrase from the archaeon Methanosarcina thermophila., Kisker C, Schindelin H, Alber BE, Ferry JG, Rees DC, EMBO J. 1996 May 15;15(10):2323-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8665839 8665839]
 
[[Category: Carbonate dehydratase]]
[[Category: Carbonate dehydratase]]
[[Category: Carbonic Anhydrase]]
[[Category: Carbonic Anhydrase]]
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[[Category: Schindelin, H.]]
[[Category: Schindelin, H.]]
[[Category: Carbonic anhydrase]]
[[Category: Carbonic anhydrase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:57:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:01:16 2008''

Revision as of 15:01, 26 June 2008

Image:1thj.png

Template:STRUCTURE 1thj

CARBONIC ANHYDRASE FROM METHANOSARCINA


Template:ABSTRACT 8665839

About this Structure

1THJ is a Single protein structure of sequence from Methanosarcina thermophila. The following page contains interesting information on the relation of 1THJ with [Carbonic Anhydrase]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 18:01:16 2008

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