2c37

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[[Image:2c37.gif|left|200px]]
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[[Image:2c37.png|left|200px]]
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==Overview==
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{{ABSTRACT_16285928}}
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The exosome is a macromolecular complex that plays fundamental roles in the biogenesis and turnover of a large number of RNA species. Here we report the crystal structures of the Rrp41-Rrp42 core complex of the S. solfataricus exosome bound to short single-stranded RNAs and to ADP. The RNA binding cleft recognizes four nucleotides in a sequence-unspecific manner, mainly by electrostatic interactions with the phosphate groups. Interactions at the 2' hydroxyls of the sugars provide specificity for RNA over DNA. The structures show both the bound substrate and the cleaved product of the reaction, suggesting a catalytic mechanism for the 3'-5' phosphorolytic activity of the exosome.
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==About this Structure==
==About this Structure==
2C37 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. The following page contains interesting information on the relation of 2C37 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb86_1.html Exosomes]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C37 OCA].
2C37 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. The following page contains interesting information on the relation of 2C37 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb86_1.html Exosomes]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C37 OCA].
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==Reference==
 
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Structural basis of 3' end RNA recognition and exoribonucleolytic cleavage by an exosome RNase PH core., Lorentzen E, Conti E, Mol Cell. 2005 Nov 11;20(3):473-81. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16285928 16285928]
 
[[Category: Exosomes]]
[[Category: Exosomes]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Rrp41]]
[[Category: Rrp41]]
[[Category: Rrp42]]
[[Category: Rrp42]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:10:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:13:52 2008''

Revision as of 15:13, 26 June 2008

Image:2c37.png

Template:STRUCTURE 2c37

RNASE PH CORE OF THE ARCHAEAL EXOSOME IN COMPLEX WITH U8 RNA


Template:ABSTRACT 16285928

About this Structure

2C37 is a Protein complex structure of sequences from Sulfolobus solfataricus. The following page contains interesting information on the relation of 2C37 with [Exosomes]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 18:13:52 2008

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