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1dj8
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(New page: 200px<br /><applet load="1dj8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dj8, resolution 2.0Å" /> '''CRYSTAL STRUCTURE OF ...)
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Revision as of 11:12, 20 November 2007
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CRYSTAL STRUCTURE OF E. COLI PERIPLASMIC PROTEIN HDEA
Overview
The X-ray crystal structure of the Escherichia coli stress response, protein HDEA has been determined at 2.0 A resolution. The single domain, alpha-helical protein is found in the periplasmic space, where it supports, an acid resistance phenotype essential for infectivity of enteric, bacterial pathogens, such as Shigella and E. coli. Functional studies, demonstrate that HDEA is activated by a dimer-to-monomer transition at, acidic pH, leading to suppression of aggregation by acid-denatured, proteins. We suggest that HDEA may support chaperone-like functions during, the extremely acidic conditions.
About this Structure
1DJ8 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
HDEA, a periplasmic protein that supports acid resistance in pathogenic enteric bacteria., Gajiwala KS, Burley SK, J Mol Biol. 2000 Jan 21;295(3):605-12. PMID:10623550
Page seeded by OCA on Tue Nov 20 13:19:30 2007
