2hiu

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[[Image:2hiu.gif|left|200px]]
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[[Image:2hiu.png|left|200px]]
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==Overview==
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{{ABSTRACT_7749917}}
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We have determined the structure of a metastable disulphide isomer of human insulin. Although not observed for proinsulin folding or insulin-chain recombination, the isomer retains ordered secondary structure and a compact hydrophobic core. Comparison with native insulin reveals a global rearrangement in the orientation of A- and B-chains. One face of the protein's surface is nevertheless in common between native and non-native structures. This face contains receptor-binding determinants, rationalizing the partial biological activity of the isomer. Structures of native and non-native disulphide isomers also define alternative three-dimensional templates. Threading of insulin-like sequences provide an experimental realization of the inverse protein-folding problem.
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==About this Structure==
==About this Structure==
2HIU is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1hiu 1hiu]. The following page contains interesting information on the relation of 2HIU with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb14_1.html Insulin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HIU OCA].
2HIU is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1hiu 1hiu]. The following page contains interesting information on the relation of 2HIU with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb14_1.html Insulin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HIU OCA].
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==Reference==
 
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Structure of a protein in a kinetic trap., Hua QX, Gozani SN, Chance RE, Hoffmann JA, Frank BH, Weiss MA, Nat Struct Biol. 1995 Feb;2(2):129-38. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7749917 7749917]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Insulin]]
[[Category: Insulin]]
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[[Category: Hormone]]
[[Category: Hormone]]
[[Category: Insulin]]
[[Category: Insulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:20:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:18:45 2008''

Revision as of 15:18, 26 June 2008

Image:2hiu.png

Template:STRUCTURE 2hiu

NMR STRUCTURE OF HUMAN INSULIN IN 20% ACETIC ACID, ZINC-FREE, 10 STRUCTURES


Template:ABSTRACT 7749917

About this Structure

2HIU is a Protein complex structure of sequences from Homo sapiens. This structure supersedes the now removed PDB entry 1hiu. The following page contains interesting information on the relation of 2HIU with [Insulin]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 18:18:45 2008

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