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2rnm

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[[Image:2rnm.jpg|left|200px]]
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[[Image:2rnm.png|left|200px]]
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==Overview==
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{{ABSTRACT_18339938}}
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Prion and nonprion forms of proteins are believed to differ solely in their three-dimensional structure, which is therefore of paramount importance for the prion function. However, no atomic-resolution structure of the fibrillar state that is likely infectious has been reported to date. We present a structural model based on solid-state nuclear magnetic resonance restraints for amyloid fibrils from the prion-forming domain (residues 218 to 289) of the HET-s protein from the filamentous fungus Podospora anserina. On the basis of 134 intra- and intermolecular experimental distance restraints, we find that HET-s(218-289) forms a left-handed beta solenoid, with each molecule forming two helical windings, a compact hydrophobic core, at least 23 hydrogen bonds, three salt bridges, and two asparagine ladders. The structure is likely to have broad implications for understanding the infectious amyloid state.
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==About this Structure==
==About this Structure==
2RNM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Podospora_anserina Podospora anserina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNM OCA].
2RNM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Podospora_anserina Podospora anserina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNM OCA].
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==Reference==
 
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Amyloid fibrils of the HET-s(218-289) prion form a beta solenoid with a triangular hydrophobic core., Wasmer C, Lange A, Van Melckebeke H, Siemer AB, Riek R, Meier BH, Science. 2008 Mar 14;319(5869):1523-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18339938 18339938]
 
[[Category: Podospora anserina]]
[[Category: Podospora anserina]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Protein fibril]]
[[Category: Protein fibril]]
[[Category: Salt bridge]]
[[Category: Salt bridge]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:13:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:22:37 2008''

Revision as of 15:22, 26 June 2008

Image:2rnm.png

Template:STRUCTURE 2rnm

Structure of The HET-s(218-289) prion in its amyloid form obtained by solid-state NMR


Template:ABSTRACT 18339938

About this Structure

2RNM is a Single protein structure of sequence from Podospora anserina. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 18:22:37 2008

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