3psg

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[[Image:3psg.gif|left|200px]]
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==Overview==
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{{ABSTRACT_1594574}}
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The structure of porcine pepsinogen at pH 6.1 has been refined to an R-factor of 0.173 for data extending to 1.65 A. The final model contains 180 solvent molecules and lacks density for residues 157-161. The structure of this aspartic proteinase zymogen possesses many of the characteristics of pepsin, the mature enzyme. The secondary structure of the zymogen consists predominantly of beta-sheet, with an approximate 2-fold axis of symmetry. The activation peptide packs into the active site cleft, and the N-terminus (1P-9P) occupies the position of the mature N-terminus (1-9). Thus changes upon activation include excision of the activation peptide and proper relocation of the mature N-terminus. The activation peptide or residues of the displaced mature N-terminus make specific interactions with the substrate binding subsites. The active site of pepsinogen is intact; thus the lack of activity of pepsinogen is not due to a deformation of the active site. Nine ion pairs in pepsinogen may be important in the advent of activation and involve the activation peptide or regions of the mature N-terminus which are relocated in the mature enzyme. The activation peptide-pepsin junction, 44P-1, is characterized by high thermal parameters and weak density, indicating a flexible structure which would be accessible to cleavage. Pepsinogen is an appropriate model for the structures of other zymogens in the aspartic proteinase family.
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==About this Structure==
==About this Structure==
3PSG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1psg 1psg]. The following page contains interesting information on the relation of 3PSG with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb12_1.html Pepsin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PSG OCA].
3PSG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1psg 1psg]. The following page contains interesting information on the relation of 3PSG with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb12_1.html Pepsin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PSG OCA].
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==Reference==
 
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The high-resolution crystal structure of porcine pepsinogen., Hartsuck JA, Koelsch G, Remington SJ, Proteins. 1992 May;13(1):1-25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1594574 1594574]
 
[[Category: Pepsin]]
[[Category: Pepsin]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Koelsch, G.]]
[[Category: Koelsch, G.]]
[[Category: Remington, S J.]]
[[Category: Remington, S J.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:11:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:27:56 2008''

Revision as of 15:27, 26 June 2008

Image:3psg.png

Template:STRUCTURE 3psg

THE HIGH RESOLUTION CRYSTAL STRUCTURE OF PORCINE PEPSINOGEN


Template:ABSTRACT 1594574

About this Structure

3PSG is a Single protein structure of sequence from Sus scrofa. This structure supersedes the now removed PDB entry 1psg. The following page contains interesting information on the relation of 3PSG with [Pepsin]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 18:27:56 2008

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