6pfk

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[[Image:6pfk.gif|left|200px]]
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==Overview==
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{{ABSTRACT_2136935}}
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Comparison between the crystal structures of low- and high-affinity forms of phosphofructokinase shows a close coupling between the change of quaternary structure and local changes triggered by binding of the allosteric effectors. These concerted changes link all the substrate and effector sites in the tetramer, and explain the change of affinity for the cooperative substrate.
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==About this Structure==
==About this Structure==
6PFK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5pfk 5pfk]. The following page contains interesting information on the relation of 6PFK with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb50_1.html The Glycolytic Enzymes]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PFK OCA].
6PFK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5pfk 5pfk]. The following page contains interesting information on the relation of 6PFK with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb50_1.html The Glycolytic Enzymes]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PFK OCA].
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==Reference==
 
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Structural basis of the allosteric behaviour of phosphofructokinase., Schirmer T, Evans PR, Nature. 1990 Jan 11;343(6254):140-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2136935 2136935]
 
[[Category: 6-phosphofructokinase]]
[[Category: 6-phosphofructokinase]]
[[Category: Geobacillus stearothermophilus]]
[[Category: Geobacillus stearothermophilus]]
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[[Category: Kinase]]
[[Category: Kinase]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:42:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:30:43 2008''

Revision as of 15:30, 26 June 2008

Template:STRUCTURE 6pfk

PHOSPHOFRUCTOKINASE, INHIBITED T-STATE


Template:ABSTRACT 2136935

About this Structure

6PFK is a Single protein structure of sequence from Geobacillus stearothermophilus. This structure supersedes the now removed PDB entry 5pfk. The following page contains interesting information on the relation of 6PFK with [The Glycolytic Enzymes]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 18:30:43 2008

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