1gsp

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[[Image:1gsp.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1gsp| PDB=1gsp | SCENE= }}
{{STRUCTURE_1gsp| PDB=1gsp | SCENE= }}
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'''RIBONUCLEASE T1 COMPLEXED WITH 2',3'-CGPS, 1 DAY'''
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===RIBONUCLEASE T1 COMPLEXED WITH 2',3'-CGPS, 1 DAY===
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==Overview==
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{{ABSTRACT_PUBMED_9546218}}
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Here we present a time-resolved crystallographic analysis of the hydrolysis of exo (Sp) guanosine 2',3'-cyclophosphorothioate by RNase T1. The use of a slow substrate and fast crystallization methods made it possible to perform the study with conventional data-collection techniques. The results support the idea that the hydrolysis reaction proceeds through a mechanism that is the inverse of the transesterification reaction. In addition, the structures provide an explanation for the differential behavior of RNase T1 towards exo- and endo-cyclic thiophosphates.
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==About this Structure==
==About this Structure==
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[[Category: Endoribonuclease]]
[[Category: Endoribonuclease]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:57:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Jun 27 20:32:19 2008''

Revision as of 17:32, 27 June 2008

Image:1gsp.png

Template:STRUCTURE 1gsp

RIBONUCLEASE T1 COMPLEXED WITH 2',3'-CGPS, 1 DAY

Template:ABSTRACT PUBMED 9546218

About this Structure

1GSP is a Single protein structure of sequence from Aspergillus oryzae. Full crystallographic information is available from OCA.

Reference

Hydrolysis of a slow cyclic thiophosphate substrate of RNase T1 analyzed by time-resolved crystallography., Zegers I, Loris R, Dehollander G, Fattah Haikal A, Poortmans F, Steyaert J, Wyns L, Nat Struct Biol. 1998 Apr;5(4):280-3. PMID:9546218

Page seeded by OCA on Fri Jun 27 20:32:19 2008

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