103d

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{{Seed}}
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{{STRUCTURE_103d| PDB=103d | SCENE= }}
{{STRUCTURE_103d| PDB=103d | SCENE= }}
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'''THE UNUSUAL STRUCTURE OF THE HUMAN CENTROMERE (GGA)2 MOTIF: UNPAIRED GUANOSINE RESIDUES STACKED BETWEEN SHEARED G(DOT)A PAIRS'''
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===THE UNUSUAL STRUCTURE OF THE HUMAN CENTROMERE (GGA)2 MOTIF: UNPAIRED GUANOSINE RESIDUES STACKED BETWEEN SHEARED G(DOT)A PAIRS===
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==Overview==
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The centromere of human chromosomes contains multiple repeats of the DNA sequence d(TGGAA)n. This sequence has the interesting property of pairing with itself to form stable duplexes. We have determined the solution structure of the unusual DNA duplex 5'-TGGAATGGAA:TGGAATGGAA-3' at atomic resolution. The duplex contains unpaired staggered guanosine residues, which co-stack by intercalation between sheared G.A and A.G base-pairs to form an interesting new structural motif, the GA-bracketed G-stack. The TGGAA repeat unit contains six "steps", four of which are not Watson-Crick base-pairs.
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The line below this paragraph, {{ABSTRACT_PUBMED_7966337}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7966337 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7966337}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=103D OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=103D OCA].
==Reference==
==Reference==
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[[Category: Human centromere repeat]]
[[Category: Human centromere repeat]]
[[Category: Nmr]]
[[Category: Nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:24:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:06:45 2008''

Revision as of 12:06, 30 June 2008

Image:103d.png

Template:STRUCTURE 103d

THE UNUSUAL STRUCTURE OF THE HUMAN CENTROMERE (GGA)2 MOTIF: UNPAIRED GUANOSINE RESIDUES STACKED BETWEEN SHEARED G(DOT)A PAIRS

Template:ABSTRACT PUBMED 7966337

About this Structure

Full experimental information is available from OCA.

Reference

The unusual structure of the human centromere (GGA)2 motif. Unpaired guanosine residues stacked between sheared G.A pairs., Chou SH, Zhu L, Reid BR, J Mol Biol. 1994 Dec 2;244(3):259-68. PMID:7966337

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