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1dl0

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(New page: 200px<br /><applet load="1dl0" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dl0" /> '''SOLUTION STRUCTURE OF THE INSECTICIDAL NEURO...)
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Revision as of 11:15, 20 November 2007

Image:1dl0.gif

1dl0

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SOLUTION STRUCTURE OF THE INSECTICIDAL NEUROTOXIN J-ATRACOTOXIN-HV1C

Overview

We have isolated a family of insect-selective neurotoxins from the venom, of the Australian funnel-web spider that appear to be good candidates for, biopesticide engineering. These peptides, which we have named the, Janus-faced atracotoxins (J-ACTXs), each contain 36 or 37 residues, with, four disulfide bridges, and they show no homology to any sequences in the, protein/DNA databases. The three-dimensional structure of one of these, toxins reveals an extremely rare vicinal disulfide bridge that we, demonstrate to be critical for insecticidal activity. We propose that, J-ACTX comprises an ancestral protein fold that we refer to as the, disulfide-directed beta-hairpin.

About this Structure

1DL0 is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.

Reference

Discovery and characterization of a family of insecticidal neurotoxins with a rare vicinal disulfide bridge., Wang X, Connor M, Smith R, Maciejewski MW, Howden ME, Nicholson GM, Christie MJ, King GF, Nat Struct Biol. 2000 Jun;7(6):505-13. PMID:10881200

Page seeded by OCA on Tue Nov 20 13:22:41 2007

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