105d

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[[Image:105d.gif|left|200px]]
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{{Seed}}
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[[Image:105d.png|left|200px]]
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{{STRUCTURE_105d| PDB=105d | SCENE= }}
{{STRUCTURE_105d| PDB=105d | SCENE= }}
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'''SOLUTION STRUCTURES OF THE I-MOTIF TETRAMERS OF D(TCC), D(5MCCT) AND D(T5MCC). NOVEL NOE CONNECTIONS BETWEEN AMINO PROTONS AND SUGAR PROTONS'''
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===SOLUTION STRUCTURES OF THE I-MOTIF TETRAMERS OF D(TCC), D(5MCCT) AND D(T5MCC). NOVEL NOE CONNECTIONS BETWEEN AMINO PROTONS AND SUGAR PROTONS===
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==Overview==
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BACKGROUND: At slightly acid or even neutral pH, oligodeoxynucleotides that include a stretch of cytidines form a tetramer structure in which two parallel-stranded duplexes have their hemi-protonated C.C+ base pairs face-to-face and fully intercalated, in a so-called i-motif, first observed serendipitously in [d(TC5)]4. RESULTS: A high-definition structure of [d(TCC)]4 was computed on the basis of inter-residue distances corresponding to 21 NOESY cross-peaks measured at short mixing times. A similarly defined structure of [d(5mCCT)]4 was also obtained. A small number of very characteristic (amino proton)-(sugar proton) cross-peaks entails the intercalation topology. The structure is generally similar to that of [d(TC5)]4. The sequence d(T5mCC) forms two tetramers in comparable proportions. The intercalation topologies are read off the two patterns of (amino proton)-(sugar proton) cross-peaks: one is the same as in the d(TCC) tetramer, the other has the intercalated strands shifted by one base, which avoids the steric hindrance between the methyl groups of the 5mC pairs of the two duplexes. CONCLUSIONS: The structures obtained in this work and the procedures introduced to characterize them and to solve the problems linked to the symmetry of the structure provide tools for further exploring the conditions required for formation of the i-motif.
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The line below this paragraph, {{ABSTRACT_PUBMED_7743125}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7743125 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7743125}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=105D OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=105D OCA].
==Reference==
==Reference==
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[[Category: Leroy, J L.]]
[[Category: Leroy, J L.]]
[[Category: Dna]]
[[Category: Dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:24:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:20:25 2008''

Revision as of 12:20, 30 June 2008

Image:105d.png

Template:STRUCTURE 105d

SOLUTION STRUCTURES OF THE I-MOTIF TETRAMERS OF D(TCC), D(5MCCT) AND D(T5MCC). NOVEL NOE CONNECTIONS BETWEEN AMINO PROTONS AND SUGAR PROTONS

Template:ABSTRACT PUBMED 7743125

About this Structure

Full experimental information is available from OCA.

Reference

Solution structures of the i-motif tetramers of d(TCC), d(5methylCCT) and d(T5methylCC): novel NOE connections between amino protons and sugar protons., Leroy JL, Gueron M, Structure. 1995 Jan 15;3(1):101-20. PMID:7743125

Page seeded by OCA on Mon Jun 30 15:20:25 2008

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