11gs

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[[Image:11gs.gif|left|200px]]
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{{STRUCTURE_11gs| PDB=11gs | SCENE= }}
{{STRUCTURE_11gs| PDB=11gs | SCENE= }}
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'''GLUTATHIONE S-TRANSFERASE COMPLEXED WITH ETHACRYNIC ACID-GLUTATHIONE CONJUGATE (FORM II)'''
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===GLUTATHIONE S-TRANSFERASE COMPLEXED WITH ETHACRYNIC ACID-GLUTATHIONE CONJUGATE (FORM II)===
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==Overview==
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The diuretic drug ethacrynic acid, an inhibitor of pi class glutathione S-transferase, has been tested in clinical trials as an adjuvant in chemotherapy. We recently solved the crystal structure of this enzyme in complex with ethacrynic acid and its glutathione conjugate. Here we present a new structure of the ethacrynic-glutathione conjugate complex. In this structure the ethacrynic moiety of the complex is shown to bind in a completely different orientation to that previously observed. Thus there are at least two binding modes possible, an observation of great importance to the design of second generation inhibitors of the enzyme.
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(as it appears on PubMed at http://www.pubmed.gov), where 9426214 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9426214}}
==About this Structure==
==About this Structure==
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[[Category: Ethacrynic acid]]
[[Category: Ethacrynic acid]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:27:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:24:44 2008''

Revision as of 12:24, 30 June 2008

Image:11gs.png

Template:STRUCTURE 11gs

GLUTATHIONE S-TRANSFERASE COMPLEXED WITH ETHACRYNIC ACID-GLUTATHIONE CONJUGATE (FORM II)

Template:ABSTRACT PUBMED 9426214

About this Structure

11GS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The glutathione conjugate of ethacrynic acid can bind to human pi class glutathione transferase P1-1 in two different modes., Oakley AJ, Lo Bello M, Mazzetti AP, Federici G, Parker MW, FEBS Lett. 1997 Dec 8;419(1):32-6. PMID:9426214

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