178d

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{{Seed}}
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{{STRUCTURE_178d| PDB=178d | SCENE= }}
{{STRUCTURE_178d| PDB=178d | SCENE= }}
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'''CRYSTAL STRUCTURE OF A DNA DUPLEX CONTAINING 8-HYDROXYDEOXYGUANINE.ADENINE BASE-PAIRS'''
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===CRYSTAL STRUCTURE OF A DNA DUPLEX CONTAINING 8-HYDROXYDEOXYGUANINE.ADENINE BASE-PAIRS===
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==Overview==
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The crystal structure of the oligonucleotide d(CGCAAATTO8GGCG), containing the chemically modified base 8-hydroxydeoxyguanine (O8G), has been determined at 2.5-A resolution and refined to a crystallographic R-factor of 16.8%. The B-type DNA helix contains standard Watson-Crick base pairs except at the mismatch sites, where O8G adopts a syn conformation and forms hydrogen bonds to adenine in the anti conformation. The thermodynamic stability of the duplex was found by UV melting techniques to be intermediate between the native oligonucleotide d(CGCAAATTTGCG) and an oligonucleotide containing A.G mispairs d(CGCAAATTGGCG). Comparison of the structure of the O8G(syn).A(anti) base pair with those of Watson-Crick base pairs has given a reason why O8G.A base pairs are not well repaired by DNA proofreading enzymes.
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The line below this paragraph, {{ABSTRACT_PUBMED_8068665}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8068665 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8068665}}
==About this Structure==
==About this Structure==
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[[Category: Mismatched]]
[[Category: Mismatched]]
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[[Category: Modified]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:33:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:36:31 2008''

Revision as of 12:36, 30 June 2008

Image:178d.png

Template:STRUCTURE 178d

CRYSTAL STRUCTURE OF A DNA DUPLEX CONTAINING 8-HYDROXYDEOXYGUANINE.ADENINE BASE-PAIRS

Template:ABSTRACT PUBMED 8068665

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of a DNA duplex containing 8-hydroxydeoxyguanine-adenine base pairs., McAuley-Hecht KE, Leonard GA, Gibson NJ, Thomson JB, Watson WP, Hunter WN, Brown T, Biochemistry. 1994 Aug 30;33(34):10266-70. PMID:8068665

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