1dmo
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(New page: 200px<br /><applet load="1dmo" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dmo" /> '''CALMODULIN, NMR, 30 STRUCTURES'''<br /> ==O...)
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Revision as of 11:17, 20 November 2007
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CALMODULIN, NMR, 30 STRUCTURES
Overview
The solution structure of Ca(2+)-free calmodulin has been determined by, NMR spectroscopy, and is compared to the previously reported structure of, the Ca(2+)-saturated form. The removal of Ca2+ causes the interhelical, angles of four EF-hand motifs to increase by 36 degrees-44 degrees. This, leads to major changes in surface properties, including the closure of the, deep hydrophobic cavity essential for target protein recognition., Concerted movements of helices A and D with respect to B and C, and of, helices E and H with respect to F and G are likely responsible for the, cooperative Ca(2+)-binding property observed between two adjacent EF-hand, sites in the amino- and carboxy-terminal domains.
About this Structure
1DMO is a Single protein structure of sequence from Xenopus laevis. Full crystallographic information is available from OCA.
Reference
Calcium-induced conformational transition revealed by the solution structure of apo calmodulin., Zhang M, Tanaka T, Ikura M, Nat Struct Biol. 1995 Sep;2(9):758-67. PMID:7552747
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