191d

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{{STRUCTURE_191d| PDB=191d | SCENE= }}
{{STRUCTURE_191d| PDB=191d | SCENE= }}
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'''CRYSTAL STRUCTURE OF INTERCALATED FOUR-STRANDED D(C3T)'''
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===CRYSTAL STRUCTURE OF INTERCALATED FOUR-STRANDED D(C3T)===
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==Overview==
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The crystal structure of d(C3T), solved at 1.4 A resolution, reveals that the molecule forms a four-stranded intercalated complex. It consists of two parallel-stranded duplexes, each of which is held together by cytosine-protonated cytosine base pairs. The two duplexes are intercalated with each other and have opposite strand orientation. The molecule has a flat, lath-like appearance, and the covalently bonded cytosines have a slow right-handed twist of 17.1 degrees. However, there is considerable asymmetry. On one of the flat sides, the phosphate groups are rotated away from the center of the molecule. They are held in this orientation by bridging water molecules that bind the NH of cytosine and a phosphate group of an opposite chain. There is also considerable microheterogeneity in the structure. The cytosine hemiprotonation occurs even at pH 7 where stable crystals form.
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(as it appears on PubMed at http://www.pubmed.gov), where 7972115 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7972115}}
==About this Structure==
==About this Structure==
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[[Category: Quadruple helix]]
[[Category: Quadruple helix]]
[[Category: U-dna]]
[[Category: U-dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:35:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:39:28 2008''

Revision as of 12:39, 30 June 2008

Image:191d.png

Template:STRUCTURE 191d

CRYSTAL STRUCTURE OF INTERCALATED FOUR-STRANDED D(C3T)

Template:ABSTRACT PUBMED 7972115

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of intercalated four-stranded d(C3T) at 1.4 A resolution., Kang CH, Berger I, Lockshin C, Ratliff R, Moyzis R, Rich A, Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11636-40. PMID:7972115

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