192d

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{{STRUCTURE_192d| PDB=192d | SCENE= }}
{{STRUCTURE_192d| PDB=192d | SCENE= }}
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'''RECOMBINATION-LIKE STRUCTURE OF D(CCGCGG)'''
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===RECOMBINATION-LIKE STRUCTURE OF D(CCGCGG)===
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==Overview==
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We have solved the single crystal X-ray structure of the synthetic DNA hexamer d(CCGCGG). The central alternating tetramer forms a Z-DNA duplex. The initial cytosine of each strand of the duplex swings out and forms a Watson-Crick base-pair with the terminal guanine of a symmetry-related molecule. Thus, two symmetry-related DNA molecules form a twin with intermolecular base-pairs at both ends. Such a twin is additionally stabilized by a sodium ion located on a dyad axis between two DNA duplexes. The total structure has recombination-like features. It also provides a model for B/Z junctions. The crystal used in this study belongs to space group C222(1) with a = 34.33 A, b = 44.04 A and c = 38.27 A. The structure was solved by molecular replacement using partial models, and refined by molecular dynamics simulated annealing and positional treatment. The refinement has been concluded with an R-factor of 18.5% for 2377 reflections with F &gt; or = 2 sigma (F) in the resolution region 8.0 to 1.92 A. The asymmetric unit contains two strands of d(CCGCGG) and 38 water molecules.
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(as it appears on PubMed at http://www.pubmed.gov), where 7966274 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7966274}}
==About this Structure==
==About this Structure==
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[[Category: Flipped-out base]]
[[Category: Flipped-out base]]
[[Category: Z-dna]]
[[Category: Z-dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:35:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:39:41 2008''

Revision as of 12:39, 30 June 2008

Image:192d.png

Template:STRUCTURE 192d

RECOMBINATION-LIKE STRUCTURE OF D(CCGCGG)

Template:ABSTRACT PUBMED 7966274

About this Structure

Full crystallographic information is available from OCA.

Reference

Recombination-like structure of d(CCGCGG)., Malinina L, Urpi L, Salas X, Huynh-Dinh T, Subirana JA, J Mol Biol. 1994 Oct 28;243(3):484-93. PMID:7966274

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