1a06

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{{STRUCTURE_1a06| PDB=1a06 | SCENE= }}
{{STRUCTURE_1a06| PDB=1a06 | SCENE= }}
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'''CALMODULIN-DEPENDENT PROTEIN KINASE FROM RAT'''
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===CALMODULIN-DEPENDENT PROTEIN KINASE FROM RAT===
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==Overview==
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The crystal structure of calcium/calmodulin-dependent protein kinase I has been determined in the autoinhibited form. The C-terminal regulatory region of the enzyme forms a helix-loop-helix segment that extends across the two domains of the catalytic core, making multiple inhibitory interactions. Elements of the first regulatory alpha helix and the loop interfere with the binding site for peptide substrates, while the loop and the second helix interact with the ATP-binding domain to induce conformational changes that obstruct the nucleotide binding pocket. One part of the calmodulin recognition element protrudes away from the catalytic domain and is potentially available for an initial interaction with calmodulin. The structure provides a view of an intact calmodulin target and suggests that substantial structural changes will accompany kinase activation by calmodulin binding to the regulatory region.
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The line below this paragraph, {{ABSTRACT_PUBMED_8601311}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8601311 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8601311}}
==About this Structure==
==About this Structure==
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[[Category: Kinase]]
[[Category: Kinase]]
[[Category: Signal transduction]]
[[Category: Signal transduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:36:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:42:13 2008''

Revision as of 12:42, 30 June 2008

Image:1a06.png

Template:STRUCTURE 1a06

CALMODULIN-DEPENDENT PROTEIN KINASE FROM RAT

Template:ABSTRACT PUBMED 8601311

About this Structure

1A06 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structural basis for the autoinhibition of calcium/calmodulin-dependent protein kinase I., Goldberg J, Nairn AC, Kuriyan J, Cell. 1996 Mar 22;84(6):875-87. PMID:8601311

Page seeded by OCA on Mon Jun 30 15:42:13 2008

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