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1a12

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{{STRUCTURE_1a12| PDB=1a12 | SCENE= }}
{{STRUCTURE_1a12| PDB=1a12 | SCENE= }}
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'''REGULATOR OF CHROMOSOME CONDENSATION (RCC1) OF HUMAN'''
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===REGULATOR OF CHROMOSOME CONDENSATION (RCC1) OF HUMAN===
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==Overview==
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The gene encoding the regulator of chromosome condensation (RCC1) was cloned by virtue of its ability to complement the temperature-sensitive phenotype of the hamster cell line tsBN2, which undergoes premature chromosome condensation or arrest in the G1 phase of the cell cycle at non-permissive temperatures. RCC1 homologues have been identified in many eukaryotes, including budding and fission yeast. Mutations in the gene affect pre-messenger RNA processing and transport, mating, initiation of mitosis and chromatin decondensation, suggesting that RCC1 is important in the control of nucleo-cytoplasmic transport and the cell cycle. Biochemically, RCC1 is a guanine-nucleotide-exchange factor for the nuclear Ras homologue Ran; it increases the dissociation of Ran-bound GDP by 10(5)-fold. It may also bind to DNAvia a protein-protein complex. Here we show that the structure of human RCC1, solved to 1.7-A resolution by X-ray crystallography, consists of a seven-bladed propeller formed from internal repeats of 51-68 residues per blade. The sequence and structure of the repeats differ from those of WD40-domain proteins, which also form seven-bladed propellers and include the beta-subunits of G proteins. The nature of the structure explains the consequences of a wide range of known mutations. The region of the protein that is involved in guanine-nucleotide exchange is located opposite the region that is thought to be involved in chromosome binding.
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==About this Structure==
==About this Structure==
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[[Category: Ran]]
[[Category: Ran]]
[[Category: Ras-like nuclear gtp binding protein]]
[[Category: Ras-like nuclear gtp binding protein]]
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Revision as of 12:45, 30 June 2008

Image:1a12.png

Template:STRUCTURE 1a12

REGULATOR OF CHROMOSOME CONDENSATION (RCC1) OF HUMAN

Template:ABSTRACT PUBMED 9510255

About this Structure

1A12 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The 1.7 A crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-bladed propeller., Renault L, Nassar N, Vetter I, Becker J, Klebe C, Roth M, Wittinghofer A, Nature. 1998 Mar 5;392(6671):97-101. PMID:9510255

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