1a1r

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[[Image:1a1r.gif|left|200px]]
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{{STRUCTURE_1a1r| PDB=1a1r | SCENE= }}
{{STRUCTURE_1a1r| PDB=1a1r | SCENE= }}
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'''HCV NS3 PROTEASE DOMAIN:NS4A PEPTIDE COMPLEX'''
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===HCV NS3 PROTEASE DOMAIN:NS4A PEPTIDE COMPLEX===
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==Overview==
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An estimated 1% of the global human population is infected by hepatitis C viruses (HCVs), and there are no broadly effective treatments for the debilitating progression of chronic hepatitis C. A serine protease located within the HCV NS3 protein processes the viral polyprotein at four specific sites and is considered essential for replication. Thus, it emerges as an attractive target for drug design. We report here the 2.5 angstrom resolution X-ray crystal structure of the NS3 protease domain complexed with a synthetic NS4A activator peptide. The protease has a chymotrypsin-like fold and features a tetrahedrally coordinated metal ion distal to the active site. The NS4A peptide intercalates within a beta sheet of the enzyme core.
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(as it appears on PubMed at http://www.pubmed.gov), where 8861917 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8861917}}
==About this Structure==
==About this Structure==
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[[Category: Serine protease]]
[[Category: Serine protease]]
[[Category: Viral protein]]
[[Category: Viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:40:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:48:28 2008''

Revision as of 12:48, 30 June 2008

Image:1a1r.png

Template:STRUCTURE 1a1r

HCV NS3 PROTEASE DOMAIN:NS4A PEPTIDE COMPLEX

Template:ABSTRACT PUBMED 8861917

About this Structure

1A1R is a Protein complex structure of sequences from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide., Kim JL, Morgenstern KA, Lin C, Fox T, Dwyer MD, Landro JA, Chambers SP, Markland W, Lepre CA, O'Malley ET, Harbeson SL, Rice CM, Murcko MA, Caron PR, Thomson JA, Cell. 1996 Oct 18;87(2):343-55. PMID:8861917

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