1a1w

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1a1w.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1a1w.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1a1w| PDB=1a1w | SCENE= }}
{{STRUCTURE_1a1w| PDB=1a1w | SCENE= }}
-
'''FADD DEATH EFFECTOR DOMAIN, F25Y MUTANT, NMR MINIMIZED AVERAGE STRUCTURE'''
+
===FADD DEATH EFFECTOR DOMAIN, F25Y MUTANT, NMR MINIMIZED AVERAGE STRUCTURE===
-
==Overview==
+
<!--
-
When activated, membrane-bound receptors for Fas and tumour-necrosis factor initiate programmed cell death by recruiting the death domain of the adaptor protein FADD to the membrane. FADD then activates caspase 8 (also known as FLICE or MACH) through an interaction between the death-effector domains of FADD and caspase 8. This ultimately leads to the apoptotic response. Death-effector domains and homologous protein modules known as caspase-recruitment domains have been found in several proteins and are important regulators of caspase (FLICE) activity and of apoptosis. Here we describe the solution structure of a soluble, biologically active mutant of the FADD death-effector domain. The structure consists of six antiparallel, amphipathic alpha-helices and resembles the overall fold of the death domains of Fas and p75. Despite this structural similarity, mutations that inhibit protein-protein interactions involving the Fas death domain have no effect when introduced into the FADD death-effector domain. Instead, a hydrophobic region of the FADD death-effector domain that is not present in the death domains is vital for binding to FLICE and for apoptotic activity.
+
The line below this paragraph, {{ABSTRACT_PUBMED_9582077}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 9582077 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_9582077}}
==About this Structure==
==About this Structure==
-
1A1W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A1W OCA].
+
1A1W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A1W OCA].
==Reference==
==Reference==
Line 30: Line 34:
[[Category: Apoptosis]]
[[Category: Apoptosis]]
[[Category: Death effector domain]]
[[Category: Death effector domain]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:41:20 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:49:08 2008''

Revision as of 12:49, 30 June 2008

Image:1a1w.png

Template:STRUCTURE 1a1w

FADD DEATH EFFECTOR DOMAIN, F25Y MUTANT, NMR MINIMIZED AVERAGE STRUCTURE

Template:ABSTRACT PUBMED 9582077

About this Structure

1A1W is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

NMR structure and mutagenesis of the FADD (Mort1) death-effector domain., Eberstadt M, Huang B, Chen Z, Meadows RP, Ng SC, Zheng L, Lenardo MJ, Fesik SW, Nature. 1998 Apr 30;392(6679):941-5. PMID:9582077

Page seeded by OCA on Mon Jun 30 15:49:08 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1a1w"
Personal tools