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1a2a

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{{STRUCTURE_1a2a| PDB=1a2a | SCENE= }}
{{STRUCTURE_1a2a| PDB=1a2a | SCENE= }}
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'''AGKISTROTOXIN, A PHOSPHOLIPASE A2-TYPE PRESYNAPTIC NEUROTOXIN FROM AGKISTRODON HALYS PALLAS'''
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===AGKISTROTOXIN, A PHOSPHOLIPASE A2-TYPE PRESYNAPTIC NEUROTOXIN FROM AGKISTRODON HALYS PALLAS===
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==Overview==
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The crystal structure of agkistrodotoxin containing eight copies of molecules in the asymmetric unit has been determined at 2.8 A resolution to a crystallographic R factor of 0.207 by the molecular replacement technique. Two spatially adjacent regions of agkistrodotoxin molecule, turn 55-61 and stretch 85-91, are remarkably different from those of non-neurotoxic isoforms in conformation and electrostatic characteristics. These regions are likely to be involved in the recognition of agkistrodotoxin towards the specific receptor at the presynaptic membrane. The structural comparison of the interfacial recognition site with non-neurotoxic isoforms reveals a decreased hydrophobicity and lack of residues with bulky hydrophobic side-chains (i.e. Trp) to serve as membrane anchors. This structural feature of agkistrodotoxin may be related to the reduced non-specific binding of the toxin to non-targeted membrane before it arrives at the presynaptic membrane and recognizes the putative receptor. A unique hydrophobic patch including residues I19, P20, F21, A23, F24, M118 and F119 is found on the surface of the molecule near the entrance of the hydrophobic channel which plays an important role in crystal packing. The interaction mode between the patches might give a clue to the binding of the neurotoxin on the membrane. The agkistrodotoxin molecules in the asymmetric unit form two tetramers and each tetramer exhibits a novel "dimer of dimers"-like structure. A molecule-spanning four-stranded antiparallel beta-sheet is formed by the beta-wings of two molecules within a tetramer.
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{{ABSTRACT_PUBMED_9733637}}
==About this Structure==
==About this Structure==
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[[Category: Phospholipase a2]]
[[Category: Phospholipase a2]]
[[Category: Presynaptic neurotoxin]]
[[Category: Presynaptic neurotoxin]]
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Revision as of 12:50, 30 June 2008

Image:1a2a.png

Template:STRUCTURE 1a2a

AGKISTROTOXIN, A PHOSPHOLIPASE A2-TYPE PRESYNAPTIC NEUROTOXIN FROM AGKISTRODON HALYS PALLAS

Template:ABSTRACT PUBMED 9733637

About this Structure

1A2A is a Single protein structure of sequence from Gloydius halys. Full crystallographic information is available from OCA.

Reference

Crystal structure of agkistrodotoxin, a phospholipase A2-type presynaptic neurotoxin from agkistrodon halys pallas., Tang L, Zhou YC, Lin ZJ, J Mol Biol. 1998 Sep 11;282(1):1-11. PMID:9733637

Page seeded by OCA on Mon Jun 30 15:50:33 2008

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