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1a32

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{{STRUCTURE_1a32| PDB=1a32 | SCENE= }}
{{STRUCTURE_1a32| PDB=1a32 | SCENE= }}
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'''RIBOSOMAL PROTEIN S15 FROM BACILLUS STEAROTHERMOPHILUS'''
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===RIBOSOMAL PROTEIN S15 FROM BACILLUS STEAROTHERMOPHILUS===
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==Overview==
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BACKGROUND: Ribosomal protein S15 is a primary RNA-binding protein that binds to the central domain of 16S rRNA. S15 also regulates its own synthesis by binding to its own mRNA. The binding sites for S15 on both mRNA and rRNA have been narrowed down to less than a hundred nucleotides each, making the protein an attractive candidate for the study of protein-RNA interactions. RESULTS: The crystal structure of S15 from Bacillus stearothermophilus has been solved to 2.1 A resolution. The structure consists of four alpha helices. Three of these helices form the core of the protein, while the N-terminal helix protrudes out from the body of the molecule to make contacts with a neighboring molecule in the crystal lattice. S15 contains a large conserved patch of basic residues which could provide a site for binding 16S rRNA. CONCLUSIONS: The conformation of the N-terminal alpha helix is quite different from that reported in a recent NMR structure of S15 from Thermus thermophilus. The intermolecular contacts that this alpha helix makes with a neighboring molecule in the crystal, however, closely resemble the intramolecular contacts that occur in the NMR structure. This conformational variability of the N-terminal helix has implications for the range of possible S15-RNA interactions. A large, conserved basic patch at one end of S15 and a cluster of conserved but exposed aromatic residues at the other end provide two possible RNA-binding sites on S15.
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(as it appears on PubMed at http://www.pubmed.gov), where 9562554 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9562554}}
==About this Structure==
==About this Structure==
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[[Category: Rna-binding]]
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[[Category: X-ray crystallography]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:53:40 2008''

Revision as of 12:53, 30 June 2008

Image:1a32.png

Template:STRUCTURE 1a32

RIBOSOMAL PROTEIN S15 FROM BACILLUS STEAROTHERMOPHILUS

Template:ABSTRACT PUBMED 9562554

About this Structure

1A32 is a Single protein structure of sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.

Reference

Conformational variability of the N-terminal helix in the structure of ribosomal protein S15., Clemons WM Jr, Davies C, White SW, Ramakrishnan V, Structure. 1998 Apr 15;6(4):429-38. PMID:9562554

Page seeded by OCA on Mon Jun 30 15:53:40 2008

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