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1a3o

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[[Image:1a3o.gif|left|200px]]
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{{Seed}}
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[[Image:1a3o.png|left|200px]]
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{{STRUCTURE_1a3o| PDB=1a3o | SCENE= }}
{{STRUCTURE_1a3o| PDB=1a3o | SCENE= }}
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'''ARTIFICIAL MUTANT (ALPHA Y42H) OF DEOXY HEMOGLOBIN'''
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===ARTIFICIAL MUTANT (ALPHA Y42H) OF DEOXY HEMOGLOBIN===
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==Overview==
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The structures of deoxy human haemoglobin and an artificial mutant (Tyralpha42--&gt;His) have been solved at 120 K. While overall agreement between these structures and others in the PDB is very good, certain side chains are found to be shifted, absent from the electron-density map or in different rotamers. Non-crystallographic symmetry (NCS) is very well obeyed in the native protein, but not around the site of the changed residue in the mutant. NCS is also not obeyed by the water molecule invariably found in the alpha-chain haem pocket in room-temperature crystal structures of haemoglobin. At 120 K, this water molecule disappears from one alpha chain in the asymmetric unit but not the other.
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(as it appears on PubMed at http://www.pubmed.gov), where 10930827 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10930827}}
==About this Structure==
==About this Structure==
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[[Category: Oxygen transport]]
[[Category: Oxygen transport]]
[[Category: Respiratory protein]]
[[Category: Respiratory protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:45:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:56:22 2008''

Revision as of 12:56, 30 June 2008

Image:1a3o.png

Template:STRUCTURE 1a3o

ARTIFICIAL MUTANT (ALPHA Y42H) OF DEOXY HEMOGLOBIN

Template:ABSTRACT PUBMED 10930827

About this Structure

1A3O is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structures of deoxy human haemoglobin and the mutant Hb Tyralpha42His at 120 K., Tame JR, Vallone B, Acta Crystallogr D Biol Crystallogr. 2000 Jul;56(Pt 7):805-11. PMID:10930827

Page seeded by OCA on Mon Jun 30 15:56:22 2008

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