1a4s

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{{STRUCTURE_1a4s| PDB=1a4s | SCENE= }}
{{STRUCTURE_1a4s| PDB=1a4s | SCENE= }}
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'''BETAINE ALDEHYDE DEHYDROGENASE FROM COD LIVER'''
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===BETAINE ALDEHYDE DEHYDROGENASE FROM COD LIVER===
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==Overview==
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The three-dimensional structure of betaine aldehyde dehydrogenase, the most abundant aldehyde dehydrogenase (ALDH) of cod liver, has been determined at 2.1 A resolution by the X-ray crystallographic method of molecular replacement. This enzyme represents a novel structure of the highly multiple ALDH, with at least 12 distinct classes in humans. This betaine ALDH of class 9 is different from the two recently determined ALDH structures (classes 2 and 3). Like these, the betaine ALDH structure has three domains, one coenzyme binding domain, one catalytic domain, and one oligomerization domain. Crystals grown in the presence or absence of NAD+ have very similar structures and no significant conformational change occurs upon coenzyme binding. This is probably due to the tight interactions between domains within the subunit and between subunits in the tetramer. The oligomerization domains link the catalytic domains together into two 20-stranded pleated sheet structures. The overall structure is similar to that of the tetrameric bovine class 2 and dimeric rat class 3 ALDH, but the coenzyme binding with the nicotinamide in anti conformation, resembles that of class 2 rather than of class 3.
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{{ABSTRACT_PUBMED_9792097}}
==About this Structure==
==About this Structure==
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[[Category: Aldehyde oxidation]]
[[Category: Aldehyde oxidation]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:48:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:07:30 2008''

Revision as of 13:07, 30 June 2008

Image:1a4s.png

Template:STRUCTURE 1a4s

BETAINE ALDEHYDE DEHYDROGENASE FROM COD LIVER

Template:ABSTRACT PUBMED 9792097

About this Structure

1A4S is a Single protein structure of sequence from Gadus callarias. Full crystallographic information is available from OCA.

Reference

Structure of betaine aldehyde dehydrogenase at 2.1 A resolution., Johansson K, El-Ahmad M, Ramaswamy S, Hjelmqvist L, Jornvall H, Eklund H, Protein Sci. 1998 Oct;7(10):2106-17. PMID:9792097

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