This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1a5w

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1a5w.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1a5w.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1a5w| PDB=1a5w | SCENE= }}
{{STRUCTURE_1a5w| PDB=1a5w | SCENE= }}
-
'''ASV INTEGRASE CORE DOMAIN WITH HIV-1 INTEGRASE INHIBITOR Y3'''
+
===ASV INTEGRASE CORE DOMAIN WITH HIV-1 INTEGRASE INHIBITOR Y3===
-
==Overview==
+
<!--
-
The x-ray structures of an inhibitor complex of the catalytic core domain of avian sarcoma virus integrase (ASV IN) were solved at 1.9- to 2.0-A resolution at two pH values, with and without Mn2+ cations. This inhibitor (Y-3), originally identified in a screen for inhibitors of the catalytic activity of HIV type 1 integrase (HIV-1 IN), was found in the present study to be active against ASV IN as well as HIV-1 IN. The Y-3 molecule is located in close proximity to the enzyme active site, interacts with the flexible loop, alters loop conformation, and affects the conformations of active site residues. As crystallized, a Y-3 molecule stacks against its symmetry-related mate. Preincubation of IN with metal cations does not prevent inhibition, and Y-3 binding does not prevent binding of divalent cations to IN. Three compounds chemically related to Y-3 also were investigated, but no binding was observed in the crystals. Our results identify the structural elements of the inhibitor that likely determine its binding properties.
+
The line below this paragraph, {{ABSTRACT_PUBMED_9560188}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 9560188 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_9560188}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Hiv-1 integrase inhibitor]]
[[Category: Hiv-1 integrase inhibitor]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:51:29 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:12:17 2008''

Revision as of 13:12, 30 June 2008

Image:1a5w.png

Template:STRUCTURE 1a5w

ASV INTEGRASE CORE DOMAIN WITH HIV-1 INTEGRASE INHIBITOR Y3

Template:ABSTRACT PUBMED 9560188

About this Structure

1A5W is a Single protein structure of sequence from Rous sarcoma virus. Full crystallographic information is available from OCA.

Reference

Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor., Lubkowski J, Yang F, Alexandratos J, Wlodawer A, Zhao H, Burke TR Jr, Neamati N, Pommier Y, Merkel G, Skalka AM, Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):4831-6. PMID:9560188

Page seeded by OCA on Mon Jun 30 16:12:17 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1a5w"
Personal tools