1a63

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[[Image:1a63.gif|left|200px]]
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{{STRUCTURE_1a63| PDB=1a63 | SCENE= }}
{{STRUCTURE_1a63| PDB=1a63 | SCENE= }}
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'''THE NMR STRUCTURE OF THE RNA BINDING DOMAIN OF E.COLI RHO FACTOR SUGGESTS POSSIBLE RNA-PROTEIN INTERACTIONS, 10 STRUCTURES'''
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===THE NMR STRUCTURE OF THE RNA BINDING DOMAIN OF E.COLI RHO FACTOR SUGGESTS POSSIBLE RNA-PROTEIN INTERACTIONS, 10 STRUCTURES===
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==Overview==
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Rho protein is an essential hexameric RNA-DNA helicase that binds nascent mRNA transcripts and terminates transcription in a wide variety of eubacterial species. The NMR solution structure of the RNA binding domain of rho, rho130, is presented. This structure consists of two sub-domains, an N-terminal three-helix bundle and a C-terminal beta-barrel that is structurally similar to the oligosaccharide/oligonucleotide binding (OB) fold. Chemical shift changes of rho130 upon RNA binding and previous mutagenetic analyses of intact rho suggest that residues Asp 60, Phe 62, Phe 64, and Arg 66 are critical for binding and support the hypothesis that ssRNA/ssDNA binding is localized in the beta-barrel sub-domain. On the basis of these studies and the tertiary structure of rho130, we propose that residues Asp 60, Phe 62, Phe 64, Arg 66, Tyr 80, Lys 105, and Arg 109 participate in RNA-protein interactions.
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{{ABSTRACT_PUBMED_9587002}}
==About this Structure==
==About this Structure==
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1A63 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A63 OCA].
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1A63 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A63 OCA].
==Reference==
==Reference==
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[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
[[Category: Transcription termination]]
[[Category: Transcription termination]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:51:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:13:07 2008''

Revision as of 13:13, 30 June 2008

Image:1a63.png

Template:STRUCTURE 1a63

THE NMR STRUCTURE OF THE RNA BINDING DOMAIN OF E.COLI RHO FACTOR SUGGESTS POSSIBLE RNA-PROTEIN INTERACTIONS, 10 STRUCTURES

Template:ABSTRACT PUBMED 9587002

About this Structure

1A63 is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

The NMR structure of the RNA binding domain of E. coli rho factor suggests possible RNA-protein interactions., Briercheck DM, Wood TC, Allison TJ, Richardson JP, Rule GS, Nat Struct Biol. 1998 May;5(5):393-9. PMID:9587002

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