1a65

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{{STRUCTURE_1a65| PDB=1a65 | SCENE= }}
{{STRUCTURE_1a65| PDB=1a65 | SCENE= }}
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'''TYPE-2 CU-DEPLETED LACCASE FROM COPRINUS CINEREUS'''
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===TYPE-2 CU-DEPLETED LACCASE FROM COPRINUS CINEREUS===
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==Overview==
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Laccase catalyses the oxidation of a variety of organic substrates coupled to the reduction of oxygen to water. It is widely believed to be the simplest representative of the ubiquitous blue multi-copper oxidase family. Laccase is implicated in a wide spectrum of biological activities and, in particular, plays a key role in morphogenesis, development and lignin metabolism in fungi and plants. The structure of laccase from the fungus Coprinus cinereus has been determined by X-ray crystallography at a resolution of 2.2 A. Laccase is a monomer composed of three cupredoxin-like beta-sandwich domains, similar to that found in ascorbate oxidase. In contrast to ascorbate oxidase, however, the mononuclear type-1 Cu site lacks the axial methionine ligand and so exhibits trigonal planar coordination, consistent with its elevated redox potential. Crucially, the structure is trapped in a Cu depleted form in which the putative type-2 Cu atom is completely absent, but in which the remaining type-1 and type-3 Cu sites display full occupancy. Type-2 Cu depletion has unexpected consequences for the coordination of the remaining type-3 Cu atoms.
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The line below this paragraph, {{ABSTRACT_PUBMED_9546223}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9546223 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9546223}}
==About this Structure==
==About this Structure==
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[[Category: Signal]]
[[Category: Signal]]
[[Category: Type-2 copper depleted]]
[[Category: Type-2 copper depleted]]
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Revision as of 13:13, 30 June 2008

Image:1a65.png

Template:STRUCTURE 1a65

TYPE-2 CU-DEPLETED LACCASE FROM COPRINUS CINEREUS

Template:ABSTRACT PUBMED 9546223

About this Structure

1A65 is a Single protein structure of sequence from Coprinopsis cinerea. Full crystallographic information is available from OCA.

Reference

Crystal structure of the type-2 Cu depleted laccase from Coprinus cinereus at 2.2 A resolution., Ducros V, Brzozowski AM, Wilson KS, Brown SH, Ostergaard P, Schneider P, Yaver DS, Pedersen AH, Davies GJ, Nat Struct Biol. 1998 Apr;5(4):310-6. PMID:9546223

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