1a6r

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1a6r.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1a6r.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1a6r| PDB=1a6r | SCENE= }}
{{STRUCTURE_1a6r| PDB=1a6r | SCENE= }}
-
'''GAL6 (YEAST BLEOMYCIN HYDROLASE) MUTANT C73A'''
+
===GAL6 (YEAST BLEOMYCIN HYDROLASE) MUTANT C73A===
-
==Overview==
+
<!--
-
The Gal6 protease is in a class of cysteine peptidases identified by their ability to inactivate the anti-cancer drug bleomycin. The protein forms a barrel structure with the active sites embedded in a channel as in the proteasome. In Gal6 the C termini lie in the active site clefts. We show that Gal6 acts as a carboxypeptidase on its C terminus to convert itself to an aminopeptidase and peptide ligase. The substrate specificity of the peptidase activity is determined by the position of the C terminus of Gal6 rather than the sequence of the substrate. We propose a model to explain these diverse activities and Gal6's singular ability to inactivate bleomycin.
+
The line below this paragraph, {{ABSTRACT_PUBMED_9546396}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 9546396 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_9546396}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Protease]]
[[Category: Protease]]
[[Category: Self-compartmentalizing protease]]
[[Category: Self-compartmentalizing protease]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:53:59 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:15:46 2008''

Revision as of 13:15, 30 June 2008

Image:1a6r.png

Template:STRUCTURE 1a6r

GAL6 (YEAST BLEOMYCIN HYDROLASE) MUTANT C73A

Template:ABSTRACT PUBMED 9546396

About this Structure

1A6R is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase., Zheng W, Johnston SA, Joshua-Tor L, Cell. 1998 Apr 3;93(1):103-9. PMID:9546396

Page seeded by OCA on Mon Jun 30 16:15:46 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1a6r"
Personal tools