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1a6y

From Proteopedia

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[[Image:1a6y.gif|left|200px]]
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{{Seed}}
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[[Image:1a6y.png|left|200px]]
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{{STRUCTURE_1a6y| PDB=1a6y | SCENE= }}
{{STRUCTURE_1a6y| PDB=1a6y | SCENE= }}
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'''REVERBA ORPHAN NUCLEAR RECEPTOR/DNA COMPLEX'''
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===REVERBA ORPHAN NUCLEAR RECEPTOR/DNA COMPLEX===
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==Overview==
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The nuclear hormone receptors form the largest known family of transcription factors. The current notion of receptor DNA discrimination, based solely on one major type of hexameric half-site and a highly conserved 66-residue core DNA-binding domain (DBD), does not adequately describe how more than 150 nonsteroid receptors differentiate among response elements. Here, we describe the 2.3 A crystal structure of the DNA-binding region of the orphan receptor RevErb arranged as a tandem homodimer on its optimal response element. The structure reveals the presence of a second major protein-DNA interface adjacent to the classical one involving the half-sites. A sequence comparison of orphan receptors suggests that unique minor-groove interactions involving the receptor hinge regions impart the necessary DNA and dimerization specificity.
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The line below this paragraph, {{ABSTRACT_PUBMED_9660968}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9660968 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9660968}}
==About this Structure==
==About this Structure==
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[[Category: Reverb]]
[[Category: Reverb]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:54:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:16:30 2008''

Revision as of 13:16, 30 June 2008

Image:1a6y.png

Template:STRUCTURE 1a6y

REVERBA ORPHAN NUCLEAR RECEPTOR/DNA COMPLEX

Template:ABSTRACT PUBMED 9660968

About this Structure

1A6Y is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural elements of an orphan nuclear receptor-DNA complex., Zhao Q, Khorasanizadeh S, Miyoshi Y, Lazar MA, Rastinejad F, Mol Cell. 1998 May;1(6):849-61. PMID:9660968

Page seeded by OCA on Mon Jun 30 16:16:30 2008

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