1a7a

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{{STRUCTURE_1a7a| PDB=1a7a | SCENE= }}
{{STRUCTURE_1a7a| PDB=1a7a | SCENE= }}
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'''STRUCTURE OF HUMAN PLACENTAL S-ADENOSYLHOMOCYSTEINE HYDROLASE: DETERMINATION OF A 30 SELENIUM ATOM SUBSTRUCTURE FROM DATA AT A SINGLE WAVELENGTH'''
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===STRUCTURE OF HUMAN PLACENTAL S-ADENOSYLHOMOCYSTEINE HYDROLASE: DETERMINATION OF A 30 SELENIUM ATOM SUBSTRUCTURE FROM DATA AT A SINGLE WAVELENGTH===
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==Overview==
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S-Adenosylhomocysteine (AdoHcy) hydrolase regulates all adenosylmethionine-(AdoMet) dependent transmethylations by hydrolyzing the potent feedback inhibitor AdoHcy to homocysteine and adenosine. The crystallographic structure determination of a selenomethionyl-incorporated AdoHcy hydrolase inhibitor complex was accomplished using single wavelength anomalous diffraction data and the direct methods program, Snb v2.0, which produced the positions of all 30 crystallographically distinct selenium atoms. The mode of enzyme-cofactor binding is unique, requiring interactions from two protein monomers. An unusual dual role for a catalytic water molecule in the active site is revealed in the complex with the adenosine analog 2'-hydroxy, 3'-ketocyclopent-4'-enyladenine.
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(as it appears on PubMed at http://www.pubmed.gov), where 9586999 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9586999}}
==About this Structure==
==About this Structure==
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Nad binding protein]]
[[Category: Nad binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:55:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:17:48 2008''

Revision as of 13:17, 30 June 2008

Image:1a7a.png

Template:STRUCTURE 1a7a

STRUCTURE OF HUMAN PLACENTAL S-ADENOSYLHOMOCYSTEINE HYDROLASE: DETERMINATION OF A 30 SELENIUM ATOM SUBSTRUCTURE FROM DATA AT A SINGLE WAVELENGTH

Template:ABSTRACT PUBMED 9586999

About this Structure

1A7A is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength., Turner MA, Yuan CS, Borchardt RT, Hershfield MS, Smith GD, Howell PL, Nat Struct Biol. 1998 May;5(5):369-76. PMID:9586999

Page seeded by OCA on Mon Jun 30 16:17:48 2008

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