1a7e

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{{STRUCTURE_1a7e| PDB=1a7e | SCENE= }}
{{STRUCTURE_1a7e| PDB=1a7e | SCENE= }}
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'''HYDROXOMET MYOHEMERYTHRIN FROM THEMISTE ZOSTERICOLA'''
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===HYDROXOMET MYOHEMERYTHRIN FROM THEMISTE ZOSTERICOLA===
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==Overview==
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Myohemerythrin (Mhr) is a nonheme iron oxygen carrier found in the retractor muscles of marine "peanut" worms. The X-ray crystal structures of two recombinant Themiste zostericola Mhrs are reported to a resolution of 1.8 A. Surprisingly, the met wild-type structure (R = 17.8%) was found to contain chloride bound to Fe2, while coordinated hydroxide was found in the met L103N structure (R = 18.3%). An internal water molecule was also found distal to the Fe-O-Fe center of the mutant protein, forming hydrogen bonds with the coordinated hydroxide and the OD1 atom of Asn-103. This finding is consistent with the kinetic and spectroscopic results reported for the L103N mutant Mhr [Raner, G. M., Martins, L. J., &amp; Ellis, W. R., Jr. (1997) Biochemistry 36, 7037-7043]. Possible roles for the side chain of residue 103 (Leu in wild-type Mhr) in gating ligand binding are also discussed.
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(as it appears on PubMed at http://www.pubmed.gov), where 9188702 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9188702}}
==About this Structure==
==About this Structure==
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[[Category: Nonheme iron oxygen carrier]]
[[Category: Nonheme iron oxygen carrier]]
[[Category: Oxygen transport]]
[[Category: Oxygen transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:55:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:18:09 2008''

Revision as of 13:18, 30 June 2008

Image:1a7e.png

Template:STRUCTURE 1a7e

HYDROXOMET MYOHEMERYTHRIN FROM THEMISTE ZOSTERICOLA

Template:ABSTRACT PUBMED 9188702

About this Structure

1A7E is a Single protein structure of sequence from Themiste zostericola. Full crystallographic information is available from OCA.

Reference

Structures of wild-type chloromet and L103N hydroxomet Themiste zostericola myohemerythrins at 1.8 A resolution., Martins LJ, Hill CP, Ellis WR Jr, Biochemistry. 1997 Jun 10;36(23):7044-9. PMID:9188702

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