1a7x

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[[Image:1a7x.gif|left|200px]]
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{{Seed}}
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[[Image:1a7x.png|left|200px]]
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{{STRUCTURE_1a7x| PDB=1a7x | SCENE= }}
{{STRUCTURE_1a7x| PDB=1a7x | SCENE= }}
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'''FKBP12-FK1012 COMPLEX'''
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===FKBP12-FK1012 COMPLEX===
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==Overview==
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A ligand that simultaneously binds two proteins must have two high affinity protein binding domains joined in a fashion that facilitates, or at least does not prevent, protein-protein interaction. Designing such ligands is challenging, and a high resolution X-ray structure of FKBP12-FK1012A-FKBP12 illustrates the subtleties of one successful design.
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The line below this paragraph, {{ABSTRACT_PUBMED_9871618}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9871618 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9871618}}
==About this Structure==
==About this Structure==
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[[Category: Immunophilin]]
[[Category: Immunophilin]]
[[Category: Isomerase]]
[[Category: Isomerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:56:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:20:03 2008''

Revision as of 13:20, 30 June 2008

Image:1a7x.png

Template:STRUCTURE 1a7x

FKBP12-FK1012 COMPLEX

Template:ABSTRACT PUBMED 9871618

About this Structure

1A7X is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Chemical inducers of dimerization: the atomic structure of FKBP12-FK1012A-FKBP12., Schultz LW, Clardy J, Bioorg Med Chem Lett. 1998 Jan 6;8(1):1-6. PMID:9871618

Page seeded by OCA on Mon Jun 30 16:20:03 2008

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