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1a8a

From Proteopedia

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[[Image:1a8a.gif|left|200px]]
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[[Image:1a8a.png|left|200px]]
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{{STRUCTURE_1a8a| PDB=1a8a | SCENE= }}
{{STRUCTURE_1a8a| PDB=1a8a | SCENE= }}
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'''RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOSERINE'''
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===RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOSERINE===
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==Overview==
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Structural evidence is presented for a 'Ca(2+)-bridging' mechanism, proposed for Ca(2+)-binding interfacial membrane proteins such as annexins, protein kinase C, and certain coagulation proteins. Crystal structures of Ca(2+)-annexin V complexes with phospholipid polar heads provide molecular details of 'Ca(2+)-bridges' as key features in the membrane attachment exhibited by these proteins. Distinct binding sites for phospholipid head groups are observed, including a novel, double-Ca2+ recognition site for phosphoserine that may serve as a phosphatidylserine receptor site in vivo.
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(as it appears on PubMed at http://www.pubmed.gov), where 7583670 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7583670}}
==About this Structure==
==About this Structure==
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[[Category: Membrane binding protein]]
[[Category: Membrane binding protein]]
[[Category: Phospholipid analog]]
[[Category: Phospholipid analog]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:57:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:21:20 2008''

Revision as of 13:21, 30 June 2008

Image:1a8a.png

Template:STRUCTURE 1a8a

RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOSERINE

Template:ABSTRACT PUBMED 7583670

About this Structure

1A8A is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Ca(2+)-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V., Swairjo MA, Concha NO, Kaetzel MA, Dedman JR, Seaton BA, Nat Struct Biol. 1995 Nov;2(11):968-74. PMID:7583670

Page seeded by OCA on Mon Jun 30 16:21:20 2008

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