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1a8j

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[[Image:1a8j.gif|left|200px]]
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[[Image:1a8j.png|left|200px]]
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{{STRUCTURE_1a8j| PDB=1a8j | SCENE= }}
{{STRUCTURE_1a8j| PDB=1a8j | SCENE= }}
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'''IMMUNOGLOBULIN LAMBDA LIGHT CHAIN DIMER (MCG) COMPLEX WITH ASPARTAME'''
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===IMMUNOGLOBULIN LAMBDA LIGHT CHAIN DIMER (MCG) COMPLEX WITH ASPARTAME===
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==Overview==
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OBJECTIVE: The binding of sweet-tasting compounds in a human (Mcg) Bence-Jones dimer has been characterized by x-ray crystallography. Aspartame binding in this immunoglobulin fragment is remarkable. Unexpected pain relief noted by A.B.E., a crystallographer with diagnosed osteoarthritis, suggested that the accommodation of aspartame in the active site of the dimer may represent surrogate binding by other proteins, with analgesia as the outcome. METHODS: X-ray analysis of the complex of aspartame and the Bence-Jones dimer was conducted with crystalline Mcg protein and pure aspartame. A single-blind (n = 1) study to confirm analgesia was completed by administration of aspartame to A.B.E. A controlled double-blind trial was performed in patients with x-ray-documented osteoarthritis. Pain and performance changes were evaluated with use of two doses of placebo and two doses of aspartame. Effects on bleeding time were then evaluated by determination of template bleeding times in 34 normal volunteers. Finally, antipyretic effects were studied in Sprague-Dawley rats given intramuscular turpentine injections. RESULTS: Aspartame binding in the Bence-Jones dimer was verified by x-ray crystallography. Improvements in performance and pain relief were observed in A.B.E. at p &lt; 0.001. Decreased pain and improved performance were also observed in patients with osteoarthritis (p &lt; 0.001). Mild antihemostatic responses were observed in bleeding times after aspartame treatment. Modified template bleeding times increased at p &lt; 0.01. Aspartame blocked the turpentine-mediated febrile responses in the treated rats (p &lt; 0.01). CONCLUSIONS: L-Aspartyl-L-phenylalanine methyl ester is biologically active and appears to relieve pain, induce mild antithrombotic effects in humans, and decrease fever in animals.
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{{ABSTRACT_PUBMED_9630831}}
==About this Structure==
==About this Structure==
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[[Category: Ligand binding]]
[[Category: Ligand binding]]
[[Category: Surrogate receptor]]
[[Category: Surrogate receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:58:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:22:29 2008''

Revision as of 13:22, 30 June 2008

Image:1a8j.png

Template:STRUCTURE 1a8j

IMMUNOGLOBULIN LAMBDA LIGHT CHAIN DIMER (MCG) COMPLEX WITH ASPARTAME

Template:ABSTRACT PUBMED 9630831

About this Structure

1A8J is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Treatment of osteoarthritis with aspartame., Edmundson AB, Manion CV, Clin Pharmacol Ther. 1998 May;63(5):580-93. PMID:9630831

Page seeded by OCA on Mon Jun 30 16:22:29 2008

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