1a9m

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{{STRUCTURE_1a9m| PDB=1a9m | SCENE= }}
{{STRUCTURE_1a9m| PDB=1a9m | SCENE= }}
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'''G48H MUTANT OF HIV-1 PROTEASE IN COMPLEX WITH A PEPTIDIC INHIBITOR U-89360E'''
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===G48H MUTANT OF HIV-1 PROTEASE IN COMPLEX WITH A PEPTIDIC INHIBITOR U-89360E===
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==Overview==
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The crystal structure of human immunodeficiency virus type 1 (HIV-1) protease mutant G48H with peptidic inhibitor U-89360E is described. Comparison with wild-type protease-inhibitor complex shows that mutation of flap residue 48 to histidine allows stabilizing van der Waals contacts between the side chains of His48 and Phe53 as well as between His48 and the P2' and P3' inhibitor subsites. The flap region is less mobile than in the wild-type enzyme. A model of saquinavir-resistant mutant protease G48V in complex with saquinavir predicts interactions similar to those found in the G48H crystal. Energetic calculations confirm the similarity of the His48 and Val48 interactions.
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(as it appears on PubMed at http://www.pubmed.gov), where 9450540 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9450540}}
==About this Structure==
==About this Structure==
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[[Category: Drug resistant]]
[[Category: Drug resistant]]
[[Category: Mutation]]
[[Category: Mutation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:26:15 2008''

Revision as of 13:26, 30 June 2008

Image:1a9m.png

Template:STRUCTURE 1a9m

G48H MUTANT OF HIV-1 PROTEASE IN COMPLEX WITH A PEPTIDIC INHIBITOR U-89360E

Template:ABSTRACT PUBMED 9450540

About this Structure

1A9M is a Single protein structure of sequence from Human immunodeficiency virus. Full crystallographic information is available from OCA.

Reference

Structure of a G48H mutant of HIV-1 protease explains how glycine-48 replacements produce mutants resistant to inhibitor drugs., Hong L, Zhang XJ, Foundling S, Hartsuck JA, Tang J, FEBS Lett. 1997 Dec 22;420(1):11-6. PMID:9450540

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