1aa6

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[[Image:1aa6.gif|left|200px]]
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{{Seed}}
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[[Image:1aa6.png|left|200px]]
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{{STRUCTURE_1aa6| PDB=1aa6 | SCENE= }}
{{STRUCTURE_1aa6| PDB=1aa6 | SCENE= }}
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'''REDUCED FORM OF FORMATE DEHYDROGENASE H FROM E. COLI'''
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===REDUCED FORM OF FORMATE DEHYDROGENASE H FROM E. COLI===
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==Overview==
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Formate dehydrogenase H from Escherichia coli contains selenocysteine (SeCys), molybdenum, two molybdopterin guanine dinucleotide (MGD) cofactors, and an Fe4S4 cluster at the active site and catalyzes the two-electron oxidation of formate to carbon dioxide. The crystal structures of the oxidized [Mo(VI), Fe4S4(ox)] form of formate dehydrogenase H (with and without bound inhibitor) and the reduced [Mo(IV), Fe4S4(red)] form have been determined, revealing a four-domain alphabeta structure with the molybdenum directly coordinated to selenium and both MGD cofactors. These structures suggest a reaction mechanism that directly involves SeCys140 and His141 in proton abstraction and the molybdenum, molybdopterin, Lys44, and the Fe4S4 cluster in electron transfer.
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(as it appears on PubMed at http://www.pubmed.gov), where 9036855 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9036855}}
==About this Structure==
==About this Structure==
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[[Category: Selenium]]
[[Category: Selenium]]
[[Category: Selenocysteine]]
[[Category: Selenocysteine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:02:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:28:45 2008''

Revision as of 13:28, 30 June 2008

Image:1aa6.png

Template:STRUCTURE 1aa6

REDUCED FORM OF FORMATE DEHYDROGENASE H FROM E. COLI

Template:ABSTRACT PUBMED 9036855

About this Structure

1AA6 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of formate dehydrogenase H: catalysis involving Mo, molybdopterin, selenocysteine, and an Fe4S4 cluster., Boyington JC, Gladyshev VN, Khangulov SV, Stadtman TC, Sun PD, Science. 1997 Feb 28;275(5304):1305-8. PMID:9036855

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