1ab8

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[[Image:1ab8.gif|left|200px]]
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{{STRUCTURE_1ab8| PDB=1ab8 | SCENE= }}
{{STRUCTURE_1ab8| PDB=1ab8 | SCENE= }}
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'''RAT TYPE II ADENYLYL CYCLASE C2 DOMAIN/FORSKOLIN COMPLEX'''
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===RAT TYPE II ADENYLYL CYCLASE C2 DOMAIN/FORSKOLIN COMPLEX===
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==Overview==
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Mammalian adenylyl cyclases contain two conserved regions, C1 and C2, which are responsible for forskolin- and G-protein-stimulated catalysis. The structure of the C2 catalytic region of type II rat adenylyl cyclase has an alpha/beta class fold in a wreath-like dimer, which has a central cleft. Two forskolin molecules bind in hydrophobic pockets at the ends of cleft. The central part of the cleft is lined by charged residues implicated in ATP binding. Forskolin appears to activate adenylyl cyclase by promoting the assembly of the active dimer and by direct interaction within the catalytic cleft. Other adenylyl cyclase regulators act at the dimer interface or on a flexible C-terminal region.
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(as it appears on PubMed at http://www.pubmed.gov), where 9069282 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9069282}}
==About this Structure==
==About this Structure==
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[[Category: Lyase]]
[[Category: Lyase]]
[[Category: Plasmid]]
[[Category: Plasmid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:04:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:31:28 2008''

Revision as of 13:31, 30 June 2008

Image:1ab8.png

Template:STRUCTURE 1ab8

RAT TYPE II ADENYLYL CYCLASE C2 DOMAIN/FORSKOLIN COMPLEX

Template:ABSTRACT PUBMED 9069282

About this Structure

1AB8 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure of the adenylyl cyclase catalytic core., Zhang G, Liu Y, Ruoho AE, Hurley JH, Nature. 1997 Mar 20;386(6622):247-53. PMID:9069282

Page seeded by OCA on Mon Jun 30 16:31:28 2008

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