1aby

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1aby.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1aby.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1aby| PDB=1aby | SCENE= }}
{{STRUCTURE_1aby| PDB=1aby | SCENE= }}
-
'''CYANOMET RHB1.1 (RECOMBINANT HEMOGLOBIN)'''
+
===CYANOMET RHB1.1 (RECOMBINANT HEMOGLOBIN)===
-
==Overview==
+
<!--
-
The need to develop a blood substitute is now urgent because of the increasing concern over blood-transmitted viral and bacterial pathogens. Cell-free haemoglobin solutions and human haemoglobin synthesized in Escherichia coli and Saccharomyces cerevisiae have been investigated as potential oxygen-carrying substitutes for red blood cells. But these haemoglobins cannot be used as a blood substitute because (1) the oxygen affinity in the absence of 2,3-bisphosphoglycerate is too high to allow unloading of enough oxygen in the tissues, and (2) they dissociate into alpha beta dimers that are cleared rapidly by renal filtration, which can result in long-term kidney damage. We have produced a human haemoglobin using an expression vector containing one gene encoding a mutant beta-globin with decreased oxygen affinity and one duplicated, tandemly fused alpha-globin gene. Fusion of the two alpha-globin subunits increases the half-life of this haemoglobin molecule in vivo by preventing its dissociation into alpha beta dimers and therefore also eliminates renal toxicity.
+
The line below this paragraph, {{ABSTRACT_PUBMED_1552945}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 1552945 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_1552945}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Oxygen transport]]
[[Category: Oxygen transport]]
[[Category: Respiratory protein]]
[[Category: Respiratory protein]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:05:05 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:33:02 2008''

Revision as of 13:33, 30 June 2008

Image:1aby.png

Template:STRUCTURE 1aby

CYANOMET RHB1.1 (RECOMBINANT HEMOGLOBIN)

Template:ABSTRACT PUBMED 1552945

About this Structure

1ABY is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A human recombinant haemoglobin designed for use as a blood substitute., Looker D, Abbott-Brown D, Cozart P, Durfee S, Hoffman S, Mathews AJ, Miller-Roehrich J, Shoemaker S, Trimble S, Fermi G, et al., Nature. 1992 Mar 19;356(6366):258-60. PMID:1552945

Page seeded by OCA on Mon Jun 30 16:33:02 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1aby"
Personal tools