1acy

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[[Image:1acy.gif|left|200px]]
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{{Seed}}
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[[Image:1acy.png|left|200px]]
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{{STRUCTURE_1acy| PDB=1acy | SCENE= }}
{{STRUCTURE_1acy| PDB=1acy | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE PRINCIPAL NEUTRALIZING SITE OF HIV-1'''
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===CRYSTAL STRUCTURE OF THE PRINCIPAL NEUTRALIZING SITE OF HIV-1===
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==Overview==
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The crystal structure of a complex between a 24-amino acid peptide from the third variable (V3) loop of human immunodeficiency virus-type 1 (HIV-1) gp 120 and the Fab fragment of a broadly neutralizing antibody (59.1) was determined to 3 angstrom resolution. The tip of the V3 loop containing the Gly-Pro-Gly-Arg-Ala-Phe sequence adopts a double-turn conformation, which may be the basis of its conservation in many HIV-1 isolates. A complete map of the HIV-1 principal neutralizing determinant was constructed by stitching together structures of V3 loop peptides bound to 59.1 and to an isolate-specific (MN) neutralizing antibody (50.1). Structural conservation of the overlapping epitopes suggests that this biologically relevant conformation could be of use in the design of synthetic vaccines and drugs to inhibit HIV-1 entry and virus-related cellular fusion.
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The line below this paragraph, {{ABSTRACT_PUBMED_7511253}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7511253 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7511253}}
==About this Structure==
==About this Structure==
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[[Category: Ghiara, J B.]]
[[Category: Ghiara, J B.]]
[[Category: Wilson, I A.]]
[[Category: Wilson, I A.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:06:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:35:38 2008''

Revision as of 13:35, 30 June 2008

Image:1acy.png

Template:STRUCTURE 1acy

CRYSTAL STRUCTURE OF THE PRINCIPAL NEUTRALIZING SITE OF HIV-1

Template:ABSTRACT PUBMED 7511253

About this Structure

1ACY is a Protein complex structure of sequences from Human immunodeficiency virus type 1 (isolate mn) and Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the principal neutralization site of HIV-1., Ghiara JB, Stura EA, Stanfield RL, Profy AT, Wilson IA, Science. 1994 Apr 1;264(5155):82-5. PMID:7511253

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