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1adn

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[[Image:1adn.gif|left|200px]]
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[[Image:1adn.png|left|200px]]
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{{STRUCTURE_1adn| PDB=1adn | SCENE= }}
{{STRUCTURE_1adn| PDB=1adn | SCENE= }}
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'''SOLUTION STRUCTURE OF THE DNA METHYLPHOSPHOTRIESTER REPAIR DOMAIN OF ESCHERICHIA COLI ADA'''
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===SOLUTION STRUCTURE OF THE DNA METHYLPHOSPHOTRIESTER REPAIR DOMAIN OF ESCHERICHIA COLI ADA===
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==Overview==
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The Escherichia coli Ada protein repairs methyl phosphotriesters in DNA by direct, irreversible methyl transfer to one of its own cysteine residues. The methyl-transfer process appears to be autocatalyzed by coordination of the acceptor residue, Cys-69, to a tightly bound zinc ion. Upon methyl transfer, Ada acquires the ability to bind DNA sequence-specifically and thereby to induce genes that confer resistance to methylating agents. The solution structure of an N-terminal 10-kDa fragment of Ada, which retains zinc binding and DNA methyl phosphotriester repair activities, was determined using multidimensional heteronuclear nuclear magnetic resonance techniques. The structure reveals a zinc-binding motif unlike any observed thus far in transcription factors or zinc-containing enzymes and provides insight into the mechanism of metalloactivated DNA repair.
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{{ABSTRACT_PUBMED_8260490}}
==About this Structure==
==About this Structure==
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1ADN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ADN OCA].
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1ADN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ADN OCA].
==Reference==
==Reference==
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[[Category: Wagner, G.]]
[[Category: Wagner, G.]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:08:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:38:01 2008''

Revision as of 13:38, 30 June 2008

Image:1adn.png

Template:STRUCTURE 1adn

SOLUTION STRUCTURE OF THE DNA METHYLPHOSPHOTRIESTER REPAIR DOMAIN OF ESCHERICHIA COLI ADA

Template:ABSTRACT PUBMED 8260490

About this Structure

1ADN is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

Solution structure of the DNA methyl phosphotriester repair domain of Escherichia coli Ada., Myers LC, Verdine GL, Wagner G, Biochemistry. 1993 Dec 28;32(51):14089-94. PMID:8260490

Page seeded by OCA on Mon Jun 30 16:38:01 2008

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