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1ae9

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[[Image:1ae9.gif|left|200px]]
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{{Seed}}
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[[Image:1ae9.png|left|200px]]
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{{STRUCTURE_1ae9| PDB=1ae9 | SCENE= }}
{{STRUCTURE_1ae9| PDB=1ae9 | SCENE= }}
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'''STRUCTURE OF THE LAMBDA INTEGRASE CATALYTIC CORE'''
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===STRUCTURE OF THE LAMBDA INTEGRASE CATALYTIC CORE===
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==Overview==
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Lambda integrase is archetypic of site-specific recombinases that catalyze intermolecular DNA rearrangements without energetic input. DNA cleavage, strand exchange, and religation steps are linked by a covalent phosphotyrosine intermediate in which Tyr342 is attached to the 3'-phosphate of the DNA cut site. The 1.9 angstrom crystal structure of the integrase catalytic domain reveals a protein fold that is conserved in organisms ranging from archaebacteria to yeast and that suggests a model for interaction with target DNA. The attacking Tyr342 nucleophile is located on a flexible loop about 20 angstroms from a basic groove that contains all the other catalytically essential residues. This bipartite active site can account for several apparently paradoxical features of integrase family recombinases, including the capacity for both cis and trans cleavage of DNA.
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(as it appears on PubMed at http://www.pubmed.gov), where 9082984 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9082984}}
==About this Structure==
==About this Structure==
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[[Category: Integrase]]
[[Category: Integrase]]
[[Category: Site-specific recombination]]
[[Category: Site-specific recombination]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:09:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:39:54 2008''

Revision as of 13:40, 30 June 2008

Image:1ae9.png

Template:STRUCTURE 1ae9

STRUCTURE OF THE LAMBDA INTEGRASE CATALYTIC CORE

Template:ABSTRACT PUBMED 9082984

About this Structure

1AE9 is a Single protein structure of sequence from Enterobacteria phage lambda. Full crystallographic information is available from OCA.

Reference

Flexibility in DNA recombination: structure of the lambda integrase catalytic core., Kwon HJ, Tirumalai R, Landy A, Ellenberger T, Science. 1997 Apr 4;276(5309):126-31. PMID:9082984

Page seeded by OCA on Mon Jun 30 16:39:54 2008

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