1aei

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{{STRUCTURE_1aei| PDB=1aei | SCENE= }}
{{STRUCTURE_1aei| PDB=1aei | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE ANNEXIN XII HEXAMER'''
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===CRYSTAL STRUCTURE OF THE ANNEXIN XII HEXAMER===
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==Overview==
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Annexins are a family of calcium- and phospholipid-binding proteins implicated in a number of biological processes including membrane fusion and ion channel formation. The crystal structure of the annexin XII hexamer, refined at 2.8 A resolution, forms a concave disk with 3-2 symmetry, about 100 A in diameter and 70 A thick with a central hydrophilic pore. Six intermolecular Ca2+ ions are involved in hexamer formation. An additional 18 Ca2+ ions are located on the perimeter of the disk, accessible only from the side of the hexameric disk. On the basis of the hexamer structure we propose here a new mode of protein-phospholipid bilayer interaction that is distinct from the hydrophobic insertion of typical membrane proteins. This speculative model postulates the Ca(2+)-dependent insertion of the hydrophilic annexin XII hexamer into phospholipid bilayers with local reorientation of the bilayer phospholipids.
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(as it appears on PubMed at http://www.pubmed.gov), where 7477411 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7477411}}
==About this Structure==
==About this Structure==
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[[Category: Calcium/phospholipid-binding]]
[[Category: Calcium/phospholipid-binding]]
[[Category: Phospholipid]]
[[Category: Phospholipid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:09:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:40:50 2008''

Revision as of 13:40, 30 June 2008

Image:1aei.png

Template:STRUCTURE 1aei

CRYSTAL STRUCTURE OF THE ANNEXIN XII HEXAMER

Template:ABSTRACT PUBMED 7477411

About this Structure

1AEI is a Single protein structure of sequence from Hydra vulgaris. Full crystallographic information is available from OCA.

Reference

Crystal structure of the annexin XII hexamer and implications for bilayer insertion., Luecke H, Chang BT, Mailliard WS, Schlaepfer DD, Haigler HT, Nature. 1995 Nov 30;378(6556):512-5. PMID:7477411

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