1afv

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[[Image:1afv.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1afv| PDB=1afv | SCENE= }}
{{STRUCTURE_1afv| PDB=1afv | SCENE= }}
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'''HIV-1 CAPSID PROTEIN (P24) COMPLEX WITH FAB25.3'''
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===HIV-1 CAPSID PROTEIN (P24) COMPLEX WITH FAB25.3===
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==Overview==
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X-ray diffraction analysis of a human immunodeficiency virus (HIV-1) capsid (CA) protein shows that each monomer within the dimer consists of seven alpha-helices, five of which are arranged in a coiled coil-like structure. Sequence assignments were made for two of the helices, and tentative connectivity of the remainder of the protein was confirmed by the recent solution structure of a monomeric N-terminal fragment. The C-terminal third of the protein is mostly disordered in the crystal. The longest helices in the coiled coil-like structure are separated by a long, highly antigenic peptide that includes the binding site of an antibody fragment complexed with CA in the crystal. The site of binding of the Fab, the position of the antigenic loop and the site of cleavage between the matrix protein and CA establish the side of the dimer that would be on the exterior of the retroviral core.
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(as it appears on PubMed at http://www.pubmed.gov), where 8784350 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8784350}}
==About this Structure==
==About this Structure==
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[[Category: Hiv]]
[[Category: Hiv]]
[[Category: P24]]
[[Category: P24]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:12:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:45:32 2008''

Revision as of 13:45, 30 June 2008

Image:1afv.png

Template:STRUCTURE 1afv

HIV-1 CAPSID PROTEIN (P24) COMPLEX WITH FAB25.3

Template:ABSTRACT PUBMED 8784350

About this Structure

1AFV is a Protein complex structure of sequences from Human immunodeficiency virus 1 and Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of dimeric HIV-1 capsid protein., Momany C, Kovari LC, Prongay AJ, Keller W, Gitti RK, Lee BM, Gorbalenya AE, Tong L, McClure J, Ehrlich LS, Summers MF, Carter C, Rossmann MG, Nat Struct Biol. 1996 Sep;3(9):763-70. PMID:8784350

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