1ah1

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{{STRUCTURE_1ah1| PDB=1ah1 | SCENE= }}
{{STRUCTURE_1ah1| PDB=1ah1 | SCENE= }}
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'''CTLA-4, NMR, 20 STRUCTURES'''
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===CTLA-4, NMR, 20 STRUCTURES===
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==Overview==
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The structure of human CTLA-4 reveals that residues Met 99, Tyr 100 and Tyr 104 of the M99YPPPY104 motif are adjacent to a patch of charged surface residues on the A'GFCC' face of the protein. Mutation of these residues, which are conserved in the CTLA-4/CD28 family, significantly reduces binding to CD80 and/or CD86, implicating this patch as a ligand binding site.
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(as it appears on PubMed at http://www.pubmed.gov), where 9228944 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9228944}}
==About this Structure==
==About this Structure==
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1AH1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AH1 OCA].
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1AH1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AH1 OCA].
==Reference==
==Reference==
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[[Category: Immunoreceptor]]
[[Category: Immunoreceptor]]
[[Category: T cell receptor]]
[[Category: T cell receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:15:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:49:59 2008''

Revision as of 13:50, 30 June 2008

Image:1ah1.png

Template:STRUCTURE 1ah1

CTLA-4, NMR, 20 STRUCTURES

Template:ABSTRACT PUBMED 9228944

About this Structure

1AH1 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28., Metzler WJ, Bajorath J, Fenderson W, Shaw SY, Constantine KL, Naemura J, Leytze G, Peach RJ, Lavoie TB, Mueller L, Linsley PS, Nat Struct Biol. 1997 Jul;4(7):527-31. PMID:9228944

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