1aio

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{{STRUCTURE_1aio| PDB=1aio | SCENE= }}
{{STRUCTURE_1aio| PDB=1aio | SCENE= }}
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'''CRYSTAL STRUCTURE OF A DOUBLE-STRANDED DNA CONTAINING THE MAJOR ADDUCT OF THE ANTICANCER DRUG CISPLATIN'''
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===CRYSTAL STRUCTURE OF A DOUBLE-STRANDED DNA CONTAINING THE MAJOR ADDUCT OF THE ANTICANCER DRUG CISPLATIN===
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==Overview==
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The success of cisplatin in cancer chemotherapy derives from its ability to crosslink DNA and alter the structure. Most cisplatin-DNA adducts are intrastrand d(GpG) and d(ApG) crosslinks, which unwind and bend the duplex to facilitate the binding of proteins that contain one or more high-mobility group (HMG) domains. When HMG-domain proteins such as HMG1, IXR (intrastrand-crosslink recognition) protein from yeast, or human upstream-binding factor (hUBF) bind cisplatin intrastrand crosslinks, they can be diverted from their natural binding sites on the genome and shield the adducts from excision repair. These activities sensitize cells to cisplatin and contribute to its cytotoxic properties. Crystallographic information about the structure of cisplatin-DNA adducts has been limited to short single-stranded deoxyoligonucleotides such as cis-[Pt(NH3)2(d(pGpG))]. Here we describe the X-ray structure at 2.6 A resolution of a double-stranded DNA dodecamer containing this adduct. Our information provides, to our knowledge, the first crystallographic look at a platinated DNA duplex and should help the design of new platinum and other metal crosslinking antitumour drug candidates. Moreover, the structure reveals a unique fusion of A- and B-type DNA segments that could be of more general importance.
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(as it appears on PubMed at http://www.pubmed.gov), where 7566180 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7566180}}
==About this Structure==
==About this Structure==
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[[Category: Modified]]
[[Category: Modified]]
[[Category: Right handed dna]]
[[Category: Right handed dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:19:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:55:56 2008''

Revision as of 13:55, 30 June 2008

Image:1aio.png

Template:STRUCTURE 1aio

CRYSTAL STRUCTURE OF A DOUBLE-STRANDED DNA CONTAINING THE MAJOR ADDUCT OF THE ANTICANCER DRUG CISPLATIN

Template:ABSTRACT PUBMED 7566180

About this Structure

This structure supersedes the now removed PDB entry 1gpg. Full crystallographic information is available from OCA.

Reference

Crystal structure of double-stranded DNA containing the major adduct of the anticancer drug cisplatin., Takahara PM, Rosenzweig AC, Frederick CA, Lippard SJ, Nature. 1995 Oct 19;377(6550):649-52. PMID:7566180

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