1aip

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[[Image:1aip.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1aip| PDB=1aip | SCENE= }}
{{STRUCTURE_1aip| PDB=1aip | SCENE= }}
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'''EF-TU EF-TS COMPLEX FROM THERMUS THERMOPHILUS'''
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===EF-TU EF-TS COMPLEX FROM THERMUS THERMOPHILUS===
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==Overview==
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In order to study nucleotide exchange mechanisms in GTP-binding proteins, we have determined the crystal structure of the complex formed by the elongation factor Tu (EF-Tu) and its exchange factor Ts (EF-Ts) from Thermus thermophilus. The complex is a dyad symmetrical heterotetramer in which each EF-Tu, through a bipartite interface, interacts with two subunits of EF-Ts, explaining the need for a dimeric exchange factor. The architecture of the assembly is distinctly different from that of the corresponding heterodimeric E. coli complex, in which the monomeric E. coli EF-Ts remarkably forms essentially the same bipartite interface with EF-Tu through a sequence/structural repeat. GDP is released primarily by a Ts-induced peptide flip in the nucleotide binding pocket that disrupts hydrogen bonds to the phosphates and repositions the peptide carbonyl so as to sterically and electrostatically eject the GDP. The exchange mechanism may have useful implications for receptor-induced exchange in heterotrimeric G proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 9253415 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9253415}}
==About this Structure==
==About this Structure==
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[[Category: Gtp-binding]]
[[Category: Gtp-binding]]
[[Category: Nucleotide exchange]]
[[Category: Nucleotide exchange]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:56:01 2008''

Revision as of 13:56, 30 June 2008

Image:1aip.png

Template:STRUCTURE 1aip

EF-TU EF-TS COMPLEX FROM THERMUS THERMOPHILUS

Template:ABSTRACT PUBMED 9253415

About this Structure

1AIP is a Protein complex structure of sequences from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the EF-Tu.EF-Ts complex from Thermus thermophilus., Wang Y, Jiang Y, Meyering-Voss M, Sprinzl M, Sigler PB, Nat Struct Biol. 1997 Aug;4(8):650-6. PMID:9253415

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