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1aiv

From Proteopedia

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[[Image:1aiv.gif|left|200px]]
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{{STRUCTURE_1aiv| PDB=1aiv | SCENE= }}
{{STRUCTURE_1aiv| PDB=1aiv | SCENE= }}
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'''APO OVOTRANSFERRIN'''
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===APO OVOTRANSFERRIN===
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==Overview==
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The three-dimensional crystal structure of hen apo-ovotransferrin has been solved by molecular replacement and refined by simulated annealing and restrained least squares to a 3.0-A resolution. The final model, which comprises 5312 protein atoms (residues 1 to 686) and 28 carbohydrate atoms (from two monosaccharides attached to Asn(473)), gives an R-factor of 0.231 for the 11,989 observed reflections between 20.0- and 3.0-A resolution. In the structure, both empty iron binding clefts are in the open conformation, lending weight to the theory that Fe(3+) binding or release in transferrin proceeds via a mechanism that involves domain opening and closure. Upon opening, the domains rotate essentially as rigid bodies. The two domains of the N-lobe rotate away from one another by 53 degrees, whereas the C-lobe domains rotate away each another by 35 degrees. These rotations take place about an axis that passes through the two beta-strands, linking the domains. The domains of each lobe make different contacts with one another in the open and closed forms. These contacts form two interdomain interfaces on either side of the rotation axis, and domain opening or closing produces a see-saw motion between these two alternative close-packed interfaces. The interdomain disulfide bridge (Cys(478)-Cys(671)), found only in the C-lobe, may restrict domain opening but does not completely prevent it.
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{{ABSTRACT_PUBMED_10497206}}
==About this Structure==
==About this Structure==
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[[Category: Sacchettini, J C.]]
[[Category: Sacchettini, J C.]]
[[Category: Iron transport protein]]
[[Category: Iron transport protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:19:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:56:31 2008''

Revision as of 13:56, 30 June 2008

Image:1aiv.png

Template:STRUCTURE 1aiv

APO OVOTRANSFERRIN

Template:ABSTRACT PUBMED 10497206

About this Structure

1AIV is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

Crystal structure of hen apo-ovotransferrin. Both lobes adopt an open conformation upon loss of iron., Kurokawa H, Dewan JC, Mikami B, Sacchettini JC, Hirose M, J Biol Chem. 1999 Oct 1;274(40):28445-52. PMID:10497206

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