1aj3

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{{STRUCTURE_1aj3| PDB=1aj3 | SCENE= }}
{{STRUCTURE_1aj3| PDB=1aj3 | SCENE= }}
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'''SOLUTION STRUCTURE OF THE SPECTRIN REPEAT, NMR, 20 STRUCTURES'''
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===SOLUTION STRUCTURE OF THE SPECTRIN REPEAT, NMR, 20 STRUCTURES===
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==Overview==
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Cytoskeletal proteins belonging to the spectrin family have an elongated structure composed of repetitive units. The three-dimensional solution structure of the 16th repeat from chicken brain alpha-spectrin (R16) has been determined by NMR spectroscopy and distance geometry-simulated annealing calculations. We used a total of 1035 distance restraints, which included 719 NOE-based values obtained by applying the ambiguous restraints for iterative assignment (ARIA) method. In addition, we performed a direct refinement against 1H-chemical shifts. The final ensemble of 20 structures shows an average RMSD of 1.52 A from the mean for the backbone atoms, excluding loops and N and C termini. R16 is made up of three antiparallel alpha-helices separated by two loops, and folds into a left-handed coiled-coil.The basic unit of spectrin is an antiparallel heterodimer composed of two homologous chains, beta and alpha. These assemble a tetramer via a mechanism that relies on the completion of a single repeat by association of the partial repeats located at the C terminus of the beta-chain (two helices) and at the N terminus of the alpha-chain (one helix). This tetramer is the assemblage able to cross-link actin filaments. Model building by homology of the "tetramerization" repeat from human erythrocyte spectrin illuminates the possible role of point mutations which cause hemolytic anemias.
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(as it appears on PubMed at http://www.pubmed.gov), where 9356261 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9356261}}
==About this Structure==
==About this Structure==
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1AJ3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AJ3 OCA].
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1AJ3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AJ3 OCA].
==Reference==
==Reference==
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[[Category: Sh3 domain]]
[[Category: Sh3 domain]]
[[Category: Spectrin]]
[[Category: Spectrin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:20:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:57:23 2008''

Revision as of 13:57, 30 June 2008

Image:1aj3.png

Template:STRUCTURE 1aj3

SOLUTION STRUCTURE OF THE SPECTRIN REPEAT, NMR, 20 STRUCTURES

Template:ABSTRACT PUBMED 9356261

About this Structure

1AJ3 is a Single protein structure of sequence from Gallus gallus. Full experimental information is available from OCA.

Reference

Solution structure of the spectrin repeat: a left-handed antiparallel triple-helical coiled-coil., Pascual J, Pfuhl M, Walther D, Saraste M, Nilges M, J Mol Biol. 1997 Oct 31;273(3):740-51. PMID:9356261

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